INT34209

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Context Info
Confidence 0.20
First Reported 1986
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.29
Pain Relevance 0.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

enzyme binding (DNM2) GTPase activity (DNM2) cytoplasm (DNM2)
cytosol (DNM2) signal transduction (DNM2) nucleus (DNM2)
Anatomy Link Frequency
HeLa 1
DNM2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Dynorphin 8 100.00 Very High Very High Very High
Intracerebroventricular 1 99.98 Very High Very High Very High
opiate 1 92.16 High High
Enkephalin 1 81.72 Quite High
Morphine 1 80.92 Quite High
Opioid 2 76.84 Quite High
mu opioid receptor 1 55.28 Quite High
Pain 3 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Infection 40 98.64 Very High Very High Very High
Pressure Volume 2 Under Development 1 67.60 Quite High
Togavirus Infection 23 33.72 Quite Low
Sprains And Strains 17 5.00 Very Low Very Low Very Low
Disease 11 5.00 Very Low Very Low Very Low
Apoptosis 9 5.00 Very Low Very Low Very Low
Fever 5 5.00 Very Low Very Low Very Low
Death 4 5.00 Very Low Very Low Very Low
Viral Meningitis 4 5.00 Very Low Very Low Very Low
Arthritis 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interestingly, HeLa cells lacking Dyn-2 were largely refractory to CHIKV-infection, whereas cells transduced with a vector coding for a control shRNA were normally infected (Figure 7D).
Negative_regulation (lacking) of Dyn-2 in HeLa associated with infection
1) Confidence 0.20 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1904475 Disease Relevance 0.23 Pain Relevance 0
In the present studies, secretion of immunoreactive corticotropin releasing factor (irCRF) into the hypophysial-portal circulation was directly measured before and after intracerebroventricular administration of beta-E, DYN and naltrexone (NTX).
Negative_regulation (administration) of DYN associated with dynorphin and intracerebroventricular
2) Confidence 0.01 Published 1986 Journal Regul. Pept. Section Abstract Doc Link 3031743 Disease Relevance 0.07 Pain Relevance 0.77

General Comments

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