INT342143

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Context Info
Confidence 0.38
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.58
Pain Relevance 0.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Casr) signal transducer activity (Casr)
Anatomy Link Frequency
D cells 4
Casr (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Somatostatin 28 97.92 Very High Very High Very High
Calcitonin gene-related peptide 26 92.76 High High
peptic ulcer disease 2 68.88 Quite High
agonist 14 40.76 Quite Low
dorsal root ganglion 4 5.00 Very Low Very Low Very Low
Cholecystokinin 4 5.00 Very Low Very Low Very Low
ASIC 4 5.00 Very Low Very Low Very Low
Neuropeptide 4 5.00 Very Low Very Low Very Low
nud 4 5.00 Very Low Very Low Very Low
antagonist 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 4 83.20 Quite High
Acid Reflux 2 69.52 Quite High
Disease 2 68.88 Quite High
Ulcers 4 68.56 Quite High
Ganglion Cysts 8 5.00 Very Low Very Low Very Low
Dyspepsia 4 5.00 Very Low Very Low Very Low
Loss Of Sense Of Smell 4 5.00 Very Low Very Low Very Low
Nociception 4 5.00 Very Low Very Low Very Low
Increased Venous Pressure Under Development 4 5.00 Very Low Very Low Very Low
Gastritis 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In light of prior known actions of CaSR activation increasing gastrin and acid secretion, the net effect of CaSR ligands may depend on its relative expression in each cell type, whether stimulatory G cells or inhibitory D cells, and whether the endocrine cells are of the closed or open type.
Positive_regulation (activation) of Localization (secretion) of CaSR in D cells
1) Confidence 0.38 Published 2010 Journal Curr Gastroenterol Rep Section Body Doc Link PMC2974196 Disease Relevance 0.29 Pain Relevance 0.16
In light of prior known actions of CaSR activation increasing gastrin and acid secretion, the net effect of CaSR ligands may depend on its relative expression in each cell type, whether stimulatory G cells or inhibitory D cells, and whether the endocrine cells are of the closed or open type.
Positive_regulation (increasing) of Localization (secretion) of CaSR in D cells
2) Confidence 0.38 Published 2010 Journal Curr Gastroenterol Rep Section Body Doc Link PMC2974196 Disease Relevance 0.29 Pain Relevance 0.16

General Comments

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