INT342147

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Context Info
Confidence 0.52
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 0.52
Pain Relevance 0.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Casr) signal transducer activity (Casr)
Anatomy Link Frequency
parietal cells 3
D cells 2
G cells 1
Casr (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Somatostatin 70 97.92 Very High Very High Very High
agonist 35 94.32 High High
Calcitonin gene-related peptide 65 92.76 High High
peptic ulcer disease 5 68.88 Quite High
dorsal root ganglion 10 5.00 Very Low Very Low Very Low
Cholecystokinin 10 5.00 Very Low Very Low Very Low
ASIC 10 5.00 Very Low Very Low Very Low
Neuropeptide 10 5.00 Very Low Very Low Very Low
nud 10 5.00 Very Low Very Low Very Low
antagonist 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 10 81.04 Quite High
Acid Reflux 5 69.52 Quite High
Disease 5 68.88 Quite High
Ulcers 10 68.56 Quite High
Gastroesophageal Reflux Disease 5 60.76 Quite High
Ganglion Cysts 20 5.00 Very Low Very Low Very Low
Dyspepsia 10 5.00 Very Low Very Low Very Low
Loss Of Sense Of Smell 10 5.00 Very Low Very Low Very Low
Nociception 10 5.00 Very Low Very Low Very Low
Increased Venous Pressure Under Development 10 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In light of prior known actions of CaSR activation increasing gastrin and acid secretion, the net effect of CaSR ligands may depend on its relative expression in each cell type, whether stimulatory G cells or inhibitory D cells, and whether the endocrine cells are of the closed or open type.
Positive_regulation (increasing) of Positive_regulation (activation) of CaSR in D cells
1) Confidence 0.52 Published 2010 Journal Curr Gastroenterol Rep Section Body Doc Link PMC2974196 Disease Relevance 0.29 Pain Relevance 0.16
For these ligands, acidic pH enhanced activation of CaSR.
Positive_regulation (enhanced) of Positive_regulation (activation) of CaSR
2) Confidence 0.35 Published 2010 Journal Curr Gastroenterol Rep Section Body Doc Link PMC2974196 Disease Relevance 0.17 Pain Relevance 0.14
Because the CaSR is present on the basolateral surface of G cells and parietal cells, one consideration is that exposure to the alkaline environments (eg, the alkaline tide after gastric secretion) would further enhance CaSR activation.
Positive_regulation (enhance) of Positive_regulation (activation) of CaSR in parietal cells
3) Confidence 0.35 Published 2010 Journal Curr Gastroenterol Rep Section Body Doc Link PMC2974196 Disease Relevance 0 Pain Relevance 0.09
From pH 7.5 to 9.0, CaSR activation was enhanced, shifting the threshold concentration and effective concentration for 50% curve for Ca2+ to the left, whereas the opposite was observed with pH 5.5 to 7.5.
Positive_regulation (enhanced) of Positive_regulation (activation) of CaSR
4) Confidence 0.35 Published 2010 Journal Curr Gastroenterol Rep Section Body Doc Link PMC2974196 Disease Relevance 0.06 Pain Relevance 0.04
Because the CaSR is present on the basolateral surface of G cells and parietal cells, one consideration is that exposure to the alkaline environments (eg, the alkaline tide after gastric secretion) would further enhance CaSR activation.
Positive_regulation (enhance) of in G cells Positive_regulation (activation) of CaSR in parietal cells
5) Confidence 0.12 Published 2010 Journal Curr Gastroenterol Rep Section Body Doc Link PMC2974196 Disease Relevance 0 Pain Relevance 0.09

General Comments

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