INT342149

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Context Info
Confidence 0.36
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.47
Pain Relevance 0.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Casr) signal transducer activity (Casr)
Anatomy Link Frequency
D cells 1
Casr (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Somatostatin 42 99.52 Very High Very High Very High
Calcitonin gene-related peptide 39 96.28 Very High Very High Very High
peptic ulcer disease 3 72.40 Quite High
agonist 21 44.28 Quite Low
dorsal root ganglion 6 5.00 Very Low Very Low Very Low
Cholecystokinin 6 5.00 Very Low Very Low Very Low
ASIC 6 5.00 Very Low Very Low Very Low
Neuropeptide 6 5.00 Very Low Very Low Very Low
nud 6 5.00 Very Low Very Low Very Low
antagonist 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Gastroesophageal Reflux Disease 3 92.40 High High
Targeted Disruption 6 89.88 High High
Acid Reflux 3 73.04 Quite High
Disease 3 72.40 Quite High
Ulcers 6 72.08 Quite High
Ganglion Cysts 12 5.00 Very Low Very Low Very Low
Dyspepsia 6 5.00 Very Low Very Low Very Low
Loss Of Sense Of Smell 6 5.00 Very Low Very Low Very Low
Nociception 6 5.00 Very Low Very Low Very Low
Increased Venous Pressure Under Development 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
One stipulation is that rather than using specific motifs, the ligand binding on CaSR may occur through electrostatic interactions that screen charged side chains of amino acids or cationic charges.
CaSR Binding (binding) of
1) Confidence 0.36 Published 2010 Journal Curr Gastroenterol Rep Section Body Doc Link PMC2974196 Disease Relevance 0.09 Pain Relevance 0
Recently, the CaSR was identified on isolated rat gastric D cells, with CaSR ligands increasing somatostatin release [29••].
CaSR Binding (ligands) of in D cells associated with somatostatin
2) Confidence 0.28 Published 2010 Journal Curr Gastroenterol Rep Section Body Doc Link PMC2974196 Disease Relevance 0.29 Pain Relevance 0.17
With continued studies, we may soon better understand the nature of intragastric chemosensing and design therapies based on CaSR ligands.



CaSR Binding (ligands) of
3) Confidence 0.24 Published 2010 Journal Curr Gastroenterol Rep Section Body Doc Link PMC2974196 Disease Relevance 0.09 Pain Relevance 0.07

General Comments

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