INT342194

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Context Info
Confidence 0.64
First Reported 2010
Last Reported 2010
Negated 3
Speculated 1
Reported most in Body
Documents 1
Total Number 17
Disease Relevance 20.13
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Arl2bp) cytoskeleton (Arl2bp) nucleus (Arl2bp)
cytoplasm (Arl2bp)
Anatomy Link Frequency
plasma 4
Daudi 3
Arl2bp (Mus musculus)
Pain Link Frequency Relevance Heat
anesthesia 17 5.00 Very Low Very Low Very Low
imagery 17 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Nasopharynx Cancer 1224 99.84 Very High Very High Very High
Cancer 816 99.52 Very High Very High Very High
Epstein-barr Virus 646 98.82 Very High Very High Very High
Malignant Neoplastic Disease 170 98.72 Very High Very High Very High
Infection 17 97.52 Very High Very High Very High
Apoptosis 17 95.92 Very High Very High Very High
Genetic Predisposition To Disease 17 88.48 High High
Contagious Ecthyma 17 61.60 Quite High
Papillomavirus Infection 17 50.48 Quite High
Carcinoma 34 49.76 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This could suggest that the viral genotype is more important than the cell background to determine the extent of BART miRNA expression.
Gene_expression (expression) of BART miRNA
1) Confidence 0.64 Published 2010 Journal Virol J Section Body Doc Link PMC2974674 Disease Relevance 0.72 Pain Relevance 0
It is noteworthy that in NPC tumors as well as in the NAD+C15 LCL, miR-BART 7-3p was expressed at a higher level than the 4 other BART miRNAs.


Gene_expression (expressed) of BART associated with cancer and nasopharynx cancer
2) Confidence 0.64 Published 2010 Journal Virol J Section Body Doc Link PMC2974674 Disease Relevance 1.48 Pain Relevance 0
In contrast, no BART miRNA were detected in exosomes from Daudi and Hela cells.
Neg (no) Gene_expression (detected) of BART miRNA in Daudi
3) Confidence 0.64 Published 2010 Journal Virol J Section Body Doc Link PMC2974674 Disease Relevance 0.83 Pain Relevance 0
In contrast with the Daudi lymphoid cell line, the NAD + C15 LCL - which is latently infected by an EBV isolate derived from the C15 tumor - also has substantial expression of the BART miRNAs with a profile somehow similar to the profile of C15.
Gene_expression (expression) of BART in Daudi associated with cancer and epstein-barr virus
4) Confidence 0.64 Published 2010 Journal Virol J Section Body Doc Link PMC2974674 Disease Relevance 0.78 Pain Relevance 0
On the basis of previous publications, these microRNAs were expected to be among the most abundant BART miRNAs produced by NPC cells [4,14,15,17,18].
Gene_expression (produced) of BART associated with nasopharynx cancer
5) Confidence 0.64 Published 2010 Journal Virol J Section Body Doc Link PMC2974674 Disease Relevance 1.57 Pain Relevance 0
Detection of BART miRNAs in the plasma of xenografted NPC- bearing mice
Gene_expression (miRNAs) of BART in plasma associated with nasopharynx cancer
6) Confidence 0.55 Published 2010 Journal Virol J Section Body Doc Link PMC2974674 Disease Relevance 1.02 Pain Relevance 0
It is noteworthy that in NPC tumors as well as in the NAD+C15 LCL, miR-BART 7-3p was expressed at a higher level than the 4 other BART miRNAs.


Gene_expression (expressed) of BART associated with cancer and nasopharynx cancer
7) Confidence 0.55 Published 2010 Journal Virol J Section Body Doc Link PMC2974674 Disease Relevance 1.49 Pain Relevance 0
Elucidation of the cellular targets of BART miRNAs will be important in this respect.
Gene_expression (targets) of BART
8) Confidence 0.55 Published 2010 Journal Virol J Section Body Doc Link PMC2974674 Disease Relevance 0.67 Pain Relevance 0
Our data provide clear evidence that several BART miRNAs are secreted by C15 NPC cells in vitro in association with exosomes (Figure 3).
Gene_expression (several) of BART associated with nasopharynx cancer
9) Confidence 0.55 Published 2010 Journal Virol J Section Body Doc Link PMC2974674 Disease Relevance 1.02 Pain Relevance 0
Our panel of BART miRNAs included members of cluster 1 (miR-BART 1-5p and 5) and cluster 2 (miR-BART 7-3p, 12 and 13).
Gene_expression (panel) of BART
10) Confidence 0.55 Published 2010 Journal Virol J Section Body Doc Link PMC2974674 Disease Relevance 1.46 Pain Relevance 0
Detection of BART miRNAs in exosomes released by NPC cells in vitro
Gene_expression (miRNAs) of BART associated with nasopharynx cancer
11) Confidence 0.55 Published 2010 Journal Virol J Section Body Doc Link PMC2974674 Disease Relevance 1.46 Pain Relevance 0
Additional investigations will be required on patient plasma samples - both NPC and controls - in order to address 2 questions: 1) Are concentrations of BART miRNAs consistently greater in the plasma of NPC patients by comparison with healthy carriers and patients bearing non-NPC tumors ?
Gene_expression (miRNAs) of BART in plasma associated with cancer and nasopharynx cancer
12) Confidence 0.55 Published 2010 Journal Virol J Section Body Doc Link PMC2974674 Disease Relevance 1.25 Pain Relevance 0
Therefore, we undertook to investigate the distribution of BART miRNAs in exosomes released by malignant NPC cells.
Spec (investigate) Gene_expression (distribution) of BART associated with malignant neoplastic disease and nasopharynx cancer
13) Confidence 0.55 Published 2010 Journal Virol J Section Body Doc Link PMC2974674 Disease Relevance 1.32 Pain Relevance 0
As previously reported, no BART miRNA was detected in Daudi [4].
Neg (no) Gene_expression (detected) of BART miRNA in Daudi
14) Confidence 0.49 Published 2010 Journal Virol J Section Body Doc Link PMC2974674 Disease Relevance 1.44 Pain Relevance 0
Most viral genes are silent but some of them are consistently expressed including genes encoding for two clusters of microRNAs called BART miRNAs [3,4].
Gene_expression (expressed) of BART
15) Confidence 0.49 Published 2010 Journal Virol J Section Body Doc Link PMC2974674 Disease Relevance 0.77 Pain Relevance 0
Moreover BART miRNAs are detected in the plasma of NPC-xenografted mice or NPC patients, thus appearing as a potential source of novel tumor biomarkers.


Gene_expression (detected) of BART in plasma associated with cancer and nasopharynx cancer
16) Confidence 0.49 Published 2010 Journal Virol J Section Body Doc Link PMC2974674 Disease Relevance 1.38 Pain Relevance 0
There was no miR-BART detection in the pool of plasma samples from CAPI mice.


Neg (no) Gene_expression (detection) of BART in plasma associated with cancer
17) Confidence 0.49 Published 2010 Journal Virol J Section Body Doc Link PMC2974674 Disease Relevance 1.45 Pain Relevance 0

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