INT34220

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.01
First Reported 1982
Last Reported 1987
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 0.25
Pain Relevance 4.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (POMC, Oprl1) small molecule metabolic process (POMC) signal transducer activity (Oprl1)
cell-cell signaling (POMC) cytoplasm (POMC) extracellular space (POMC)
POMC (Homo sapiens)
Oprl1 (Mus musculus)
Pain Link Frequency Relevance Heat
Enkephalin 23 100.00 Very High Very High Very High
opiate 8 100.00 Very High Very High Very High
Morphine 6 100.00 Very High Very High Very High
Dynorphin 3 100.00 Very High Very High Very High
Endogenous opioid 6 94.64 High High
narcan 3 90.96 High High
antagonist 1 85.88 High High
agonist 3 78.28 Quite High
Dopamine 1 53.16 Quite High
Disease Link Frequency Relevance Heat
Nociception 3 84.16 Quite High
Stress 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These findings support the hypothesis that the opiate receptor population in peripheral tissues are heterogenous and that Met-enkephalin depresses exocytotic release of norepinephrine by interacting with a specific presynaptic opiate receptor.
Met-enkephalin Binding (interacting) of opiate receptor associated with enkephalin and opiate
1) Confidence 0.01 Published 1982 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 6281410 Disease Relevance 0 Pain Relevance 1.00
The three classes of endogenous opioids, originating from three distinct genes, are discussed: pro-opiomelanocortin, giving rise to beta-endorphin, ACTH and various MSHs; pro-enkephalin, giving methionine enkephalin and leucine enkephalin; and prodynorphin; their anatomical distribution and the main classes of receptors with which they interact, the mu-receptor, with a high affinity for met-enkephalin and beta-endorphin (as well as morphine and dynorphin A); the delta-receptor for which the primary ligand is leu-enkephalin; and the kappa-receptor which is the main target for the dynorphins.
beta-endorphin Binding (affinity) of kappa-receptor associated with dynorphin, endogenous opioid, enkephalin and morphine
2) Confidence 0.01 Published 1987 Journal Anaesth Intensive Care Section Abstract Doc Link 3032015 Disease Relevance 0.08 Pain Relevance 1.02
The three classes of endogenous opioids, originating from three distinct genes, are discussed: pro-opiomelanocortin, giving rise to beta-endorphin, ACTH and various MSHs; pro-enkephalin, giving methionine enkephalin and leucine enkephalin; and prodynorphin; their anatomical distribution and the main classes of receptors with which they interact, the mu-receptor, with a high affinity for met-enkephalin and beta-endorphin (as well as morphine and dynorphin A); the delta-receptor for which the primary ligand is leu-enkephalin; and the kappa-receptor which is the main target for the dynorphins.
met-enkephalin Binding (affinity) of kappa-receptor associated with dynorphin, endogenous opioid, enkephalin and morphine
3) Confidence 0.01 Published 1987 Journal Anaesth Intensive Care Section Abstract Doc Link 3032015 Disease Relevance 0.08 Pain Relevance 1.02
The three classes of endogenous opioids, originating from three distinct genes, are discussed: pro-opiomelanocortin, giving rise to beta-endorphin, ACTH and various MSHs; pro-enkephalin, giving methionine enkephalin and leucine enkephalin; and prodynorphin; their anatomical distribution and the main classes of receptors with which they interact, the mu-receptor, with a high affinity for met-enkephalin and beta-endorphin (as well as morphine and dynorphin A); the delta-receptor for which the primary ligand is leu-enkephalin; and the kappa-receptor which is the main target for the dynorphins.
met-enkephalin Binding (affinity) of kappa-receptor associated with dynorphin, endogenous opioid, enkephalin and morphine
4) Confidence 0.01 Published 1987 Journal Anaesth Intensive Care Section Abstract Doc Link 3032015 Disease Relevance 0.08 Pain Relevance 1.02

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox