INT342278

Context Info Confidence 0.03 First Reported 2010 Last Reported 2011 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 2 Disease Relevance 0.37 Pain Relevance 0.37

hydrolase activity, acting on glycosyl bonds (Lyz2) extracellular region (Lyz2) cytoplasm (Lyz2)

Anatomy Link Frequency pancreas 1 Lyz2 (Mus musculus)

Pain Link Frequency Relevance Heat agonist 9 100.00 antagonist 17 75.36 Potency 4 48.16 Hyperalgesia 1 37.16 antidepressant 1 11.04 Eae 1 5.52 depression 8 5.00 medulla 6 5.00 tolerance 6 5.00 Hippocampus 4 5.00

Disease Link Frequency Relevance Heat Diabetes Mellitus 130 72.56 Hyperinsulinism 11 70.96 Stress 84 59.44 Affective Disorder 2 55.64 Hyperalgesia 1 37.16 Aggression 17 28.84 Depression 10 23.64 Anxiety Disorder 8 23.04 Targeted Disruption 62 5.00 Sprains And Strains 12 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Three molecules of Arg and one molecule of Lys are released during this process.

Localization (released) of Lys

1) Confidence 0.03 Published 2010 Journal Rev Endocr Metab Disord Section Body Doc Link PMC2974937 Disease Relevance 0.26 Pain Relevance 0

One such member of the recent modified range of Avp analogue agonists, d[Leu4,Lys8] Avp, is noted to be a full agonist at human, rat and mouse Avpr1bs in vitro as well as stimulates ACTH and insulin release at low doses from mouse pituitary and perfused rat pancreas, respectively (Pena et al. 2007b).

Localization (release) of Lys8 in pancreas associated with agonist

2) Confidence 0.00 Published 2011 Journal Stress (Amsterdam, Netherlands) Section Body Doc Link PMC3016603 Disease Relevance 0.12 Pain Relevance 0.37

General Comments

This test has worked.