INT342281

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Context Info
Confidence 0.08
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.57
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (INS) enzyme binding (Esr1) DNA binding (Esr1)
carbohydrate metabolic process (INS) protein complex (Esr1) cytoplasm (Esr1)
INS (Homo sapiens)
Esr1 (Mus musculus)
Pain Link Frequency Relevance Heat
tolerance 6 19.20 Low Low
Potency 2 5.00 Very Low Very Low Very Low
potassium channel 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 4 99.20 Very High Very High Very High
Targeted Disruption 2 92.36 High High
Diabetes Mellitus 129 84.88 Quite High
Hypoglycemia 1 68.36 Quite High
Apoptosis 3 55.72 Quite High
Syndrome 1 30.80 Quite Low
Death 2 29.28 Quite Low
Hyperinsulinism 11 27.84 Quite Low
Impaired Glucose Tolerance 8 20.56 Low Low
Birth Weight 7 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, the aggregation of both mutant and native proinsulin in the ER likely triggers ER stress [37].


proinsulin Binding (aggregation) of ER associated with stress
1) Confidence 0.08 Published 2010 Journal Rev Endocr Metab Disord Section Body Doc Link PMC2974937 Disease Relevance 0.57 Pain Relevance 0

General Comments

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