INT342309

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Context Info
Confidence 0.02
First Reported 2011
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.10
Pain Relevance 0.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (Apaf1, Casp9) cytoplasm (Apaf1, Casp9) cytosol (Apaf1, Casp9)
nucleus (Apaf1, Casp9) cell differentiation (Apaf1) mitochondrion (Casp9)
Apaf1 (Rattus norvegicus)
Casp9 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
ischemia 18 83.28 Quite High
cytokine 3 68.48 Quite High
Inflammation 4 50.96 Quite High
cva 5 29.48 Quite Low
Inflammatory response 3 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
depression 1 5.00 Very Low Very Low Very Low
Neurobehavioral 1 5.00 Very Low Very Low Very Low
agonist 1 5.00 Very Low Very Low Very Low
isoflurane 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypoxia 5 89.00 High High
Injury 8 88.12 High High
Apoptosis 7 84.24 Quite High
Cv Unclassified Under Development 6 83.28 Quite High
Targeted Disruption 1 81.44 Quite High
Death 2 75.88 Quite High
Brain Hemorrhage 10 66.16 Quite High
Middle Cerebral Artery Infarction 30 52.44 Quite High
INFLAMMATION 7 50.96 Quite High
Cv General 4 Under Development 4 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Bax is translocated to mitochondria where it releases cytochrome c into the cytosol to interact with Apaf-1 to activate caspase-9, which in turn activates downstream caspases, such as active caspase-3 [26].
Apaf-1 Positive_regulation (activate) of caspase-9
1) Confidence 0.02 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2975073 Disease Relevance 1.10 Pain Relevance 0.13

General Comments

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