INT34233

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Context Info
Confidence 0.27
First Reported 1987
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.48
Pain Relevance 0.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (TIMP1) extracellular region (TIMP1)
Anatomy Link Frequency
macrophage 2
fibroblasts 2
TIMP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 5 99.84 Very High Very High Very High
dexamethasone 3 99.34 Very High Very High Very High
Calcium channel 1 90.48 High High
Inflammatory response 1 89.28 High High
cINOD 4 85.48 High High
sodium channel 5 84.24 Quite High
cytokine 18 78.04 Quite High
Inflammation 10 66.88 Quite High
Inflammatory mediators 1 40.36 Quite Low
anticonvulsant 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Multiple Sclerosis 1 91.60 High High
INFLAMMATION 16 88.92 High High
Gingival Overgrowth 10 24.32 Low Low
Pathologic Processes 2 5.00 Very Low Very Low Very Low
Wound Healing 2 5.00 Very Low Very Low Very Low
Convulsion 2 5.00 Very Low Very Low Very Low
Fibrosis 1 5.00 Very Low Very Low Very Low
Periodontal Disease 1 5.00 Very Low Very Low Very Low
Sprains And Strains 1 5.00 Very Low Very Low Very Low
Hyperplasia 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Uncoordinate regulation of collagenase, stromelysin, and tissue inhibitor of metalloproteinases genes by prostaglandin E2: selective enhancement of collagenase gene expression in human dermal fibroblasts in culture.
Regulation (regulation) of Negative_regulation (inhibitor) of collagenase in fibroblasts associated with metalloproteinase
1) Confidence 0.27 Published 1994 Journal J. Cell. Biochem. Section Title Doc Link 8014195 Disease Relevance 0.14 Pain Relevance 0.24
Dexamethasone inhibited PGE2 synthesis, which resulted in the suppression of collagenase.
Regulation (resulted) of Negative_regulation (suppression) of collagenase associated with dexamethasone
2) Confidence 0.26 Published 1987 Journal Cell. Immunol. Section Abstract Doc Link 3032463 Disease Relevance 0.16 Pain Relevance 0.36
Here we report a dose-dependent inhibition of macrophage function by way of suppressed supernatant levels of MMP-1, MMP-3, MMP-9, TIMP-1 and TNF-?
Regulation (way) of Negative_regulation (suppressed) of TIMP-1 in macrophage
3) Confidence 0.23 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2949711 Disease Relevance 0.18 Pain Relevance 0.17

General Comments

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