INT342381

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Context Info
Confidence 0.55
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.97
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Vdr) mitochondrion (Lrp5) cell morphogenesis (Vdr)
endoplasmic reticulum (Lrp5) nucleus (Vdr) plasma membrane (Lrp5)
Anatomy Link Frequency
body 1
Lrp5 (Mus musculus)
Vdr (Mus musculus)
Pain Link Frequency Relevance Heat
Pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress Fractures 53 99.76 Very High Very High Very High
Body Weight 9 98.32 Very High Very High Very High
Obesity 27 97.68 Very High Very High Very High
Hypophosphatemia 1 92.36 High High
Hypocalcemia 1 91.64 High High
Targeted Disruption 1 89.20 High High
Osteoporotic Fractures 2 88.32 High High
Bone Cancer 1 78.88 Quite High
Genetic Predisposition To Disease 1 50.00 Quite Low
Osteoporosis 3 39.84 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The present study indicates that the association of the LRP5 haplotype and LRP5-VDR interaction with stress fractures is mediated by low body weight and BMI, but more research is needed before any definitive conclusions can be drawn from these findings.
LRP5 Binding (interaction) of LRP5-VDR in body associated with body weight, obesity and stress fractures
1) Confidence 0.55 Published 2010 Journal BMC Genet Section Body Doc Link PMC2975640 Disease Relevance 0.97 Pain Relevance 0

General Comments

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