INT342382

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Context Info
Confidence 0.40
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.90
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Lrp5) lyase activity (Car1) endoplasmic reticulum (Lrp5)
Golgi apparatus (Car1) plasma membrane (Lrp5) cytoplasm (Car1)
Anatomy Link Frequency
neck 1
Car1 (Mus musculus)
Lrp5 (Mus musculus)
Pain Link Frequency Relevance Heat
Pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress Fractures 53 99.74 Very High Very High Very High
Femoral Neck Fractures 2 98.80 Very High Very High Very High
Obesity 27 93.08 High High
Genetic Predisposition To Disease 1 50.00 Quite Low
Nicotine Addiction 3 12.80 Low Low
Body Weight 9 5.00 Very Low Very Low Very Low
Osteoporosis 3 5.00 Very Low Very Low Very Low
Osteoporotic Fractures 2 5.00 Very Low Very Low Very Low
Disease 2 5.00 Very Low Very Low Very Low
Dislocations 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Their contribution to the risk for stress fractures revealed an interaction between the LRP5 haplotype A-G-G-C and the VDR haplotype C-A (Table 4); i.e., the risk of femoral neck fracture was marginally increased in subjects without the C-A haplotype (OR 1.78; 95% CI 0.96 - 3.30), and increased 3.85-fold (95% CI: 1.16-12.84) in carriers of both the A-G-G-C and C-A haplotypes compared with carriers of only the C-A haplotype.
C-A Binding (interaction) of LRP5 in neck associated with femoral neck fractures and stress fractures
1) Confidence 0.40 Published 2010 Journal BMC Genet Section Body Doc Link PMC2975640 Disease Relevance 0.90 Pain Relevance 0

General Comments

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