INT342503

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Context Info
Confidence 0.18
First Reported 2010
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.41
Pain Relevance 0.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

unfolded protein binding (HSP90B1) protein folding (HSP90B1) cytosol (HSP90B1)
endoplasmic reticulum (HSP90B1) RNA binding (HSP90B1) response to stress (HSP90B1)
HSP90B1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 6 79.92 Quite High
Crohn's disease 102 58.56 Quite High
Inflammation 10 5.00 Very Low Very Low Very Low
rheumatoid arthritis 2 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
abdominal pain 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Sprains And Strains 54 98.00 Very High Very High Very High
Infection 16 87.12 High High
Escherichia Infection 2 61.56 Quite High
Disease 110 58.56 Quite High
Bacterial Infection 2 54.32 Quite High
Necrosis 2 52.76 Quite High
Cancer 6 52.40 Quite High
Stress 34 50.00 Quite Low
Inflammatory Bowel Disease 24 28.28 Quite Low
INFLAMMATION 10 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, transfection of cells with control siRNA that did not reduce the Gp96 protein level did not affect the ability of AIEC strain LF82 to invade IECs.
Neg (not) Negative_regulation (reduce) of Gp96 associated with sprains and strains
1) Confidence 0.18 Published 2010 Journal Gut Section Body Doc Link PMC2976078 Disease Relevance 0.66 Pain Relevance 0.03
The role of Gp96 in AIEC invasion of IECs was investigated using invasion inhibition assays in the presence of anti-Gp96 polyclonal antibodies and by invasion assays using IECs with decreased levels of gp96 by RNA silencing.
Negative_regulation (decreased) of gp96
2) Confidence 0.18 Published 2010 Journal Gut Section Body Doc Link PMC2976078 Disease Relevance 0.75 Pain Relevance 0.14

General Comments

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