INT342506

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Context Info
Confidence 0.34
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.73
Pain Relevance 0.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

unfolded protein binding (HSP90B1) protein folding (HSP90B1) cytosol (HSP90B1)
endoplasmic reticulum (HSP90B1) RNA binding (HSP90B1) response to stress (HSP90B1)
Anatomy Link Frequency
epithelium 1
HSP90B1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Crohn's disease 102 98.80 Very High Very High Very High
Inflammation 10 89.72 High High
cytokine 6 5.00 Very Low Very Low Very Low
rheumatoid arthritis 2 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
abdominal pain 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 110 98.80 Very High Very High Very High
INFLAMMATION 10 89.72 High High
Targeted Disruption 4 88.72 High High
Sprains And Strains 54 81.64 Quite High
Stress 34 50.00 Quite Low
Pseudomonas Infection 2 30.72 Quite Low
Inflammatory Bowel Disease 24 5.00 Very Low Very Low Very Low
Infection 16 5.00 Very Low Very Low Very Low
Adhesions 8 5.00 Very Low Very Low Very Low
Meningitis 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Co-localisation of Gp96 and CEACAM6 was observed in patients with CD.
Localization (localisation) of Gp96 associated with crohn's disease
1) Confidence 0.34 Published 2010 Journal Gut Section Body Doc Link PMC2976078 Disease Relevance 0.30 Pain Relevance 0.08
Such a co-localisation of Gp96 and CEACAM6 in patients with CD at the apical side of ileal epithelial cells is of great interest, since we previously reported that CEACAM6 acts as a receptor for E coli type 1 pili and therefore allows AIEC to colonise the ileal mucosa12 and promote gut inflammation as shown in transgenic CEABAC10 mice expressing the human CEACAM6 molecule.46 Increased expression of Gp96 at the same site as CEACAM6 should increase AIEC virulence, since the bacteria would be able to colonise the mucosa by binding to CEACAM6 and can better invade the ileal epithelium through AIEC OMV–Gp96 interaction.
Localization (localisation) of Gp96 in epithelium associated with targeted disruption, inflammation and crohn's disease
2) Confidence 0.32 Published 2010 Journal Gut Section Body Doc Link PMC2976078 Disease Relevance 0.43 Pain Relevance 0.14

General Comments

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