INT342508

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Context Info
Confidence 0.25
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.81
Pain Relevance 0.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

unfolded protein binding (HSP90B1) protein folding (HSP90B1) cytosol (HSP90B1)
endoplasmic reticulum (HSP90B1) RNA binding (HSP90B1) response to stress (HSP90B1)
HSP90B1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Crohn's disease 102 97.00 Very High Very High Very High
Inflammation 10 79.04 Quite High
cytokine 6 66.92 Quite High
rheumatoid arthritis 2 31.64 Quite Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
abdominal pain 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Infection 16 99.30 Very High Very High Very High
Disease 110 97.00 Very High Very High Very High
Sprains And Strains 54 94.36 High High
Lymphatic System Cancer 2 83.32 Quite High
INFLAMMATION 10 79.04 Quite High
Stress 34 74.80 Quite High
Inflammatory Bowel Disease 24 72.76 Quite High
Targeted Disruption 4 69.60 Quite High
Congenital Anomalies 4 56.52 Quite High
Escherichia Infection 2 48.56 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We also investigated whether infection with AIEC pathogenic bacteria can interfere with Gp96 expression, but we did not observe any increase in response to AIEC infection.
Negative_regulation (interfere) of Gene_expression (expression) of Gp96 associated with infection
1) Confidence 0.25 Published 2010 Journal Gut Section Body Doc Link PMC2976078 Disease Relevance 1.24 Pain Relevance 0.19
Interestingly, reduced Gp96 expression by transfecting IECs with gp96 siRNA (figure 3B) induced decreased LF82 invasion levels (figure 3C).
Negative_regulation (reduced) of Gene_expression (expression) of Gp96
2) Confidence 0.18 Published 2010 Journal Gut Section Body Doc Link PMC2976078 Disease Relevance 0.57 Pain Relevance 0.07

General Comments

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