INT342512

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Context Info
Confidence 0.24
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.62
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

unfolded protein binding (Hsp90b1, HSP90B1) protein folding (Hsp90b1, HSP90B1) cytosol (Hsp90b1, HSP90B1)
endoplasmic reticulum (Hsp90b1, HSP90B1) RNA binding (Hsp90b1, HSP90B1) response to stress (Hsp90b1, HSP90B1)
Anatomy Link Frequency
plasma 2
Hsp90b1 (Mus musculus)
HSP90B1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Crohn's disease 51 66.04 Quite High
Inflammation 5 48.08 Quite Low
cytokine 3 5.00 Very Low Very Low Very Low
rheumatoid arthritis 1 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
abdominal pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Infection 8 100.00 Very High Very High Very High
Meningitis 3 100.00 Very High Very High Very High
Sprains And Strains 27 84.16 Quite High
Adhesions 4 80.56 Quite High
Disease 55 66.04 Quite High
Lymphatic System Cancer 1 52.36 Quite High
Stress 17 50.00 Quite Low
INFLAMMATION 5 48.08 Quite Low
Ulcers 1 42.56 Quite Low
Inflammatory Bowel Disease 12 41.80 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Gp96 has already been reported to be a key mediator of the innate immune response due to its ability to bind pathogenic bacteria or their products.19–21 37 38 Indeed, Gp96 is a plasma membrane receptor for Vip, a Listeria monocytogenes virulence factor that is required for cell invasion and downstream signalling events.21 In addition, a Gp96 homologue, Ecgp96, the expression of which is increased during meningitis-associated E coli K1 infection of human BMECs, promotes invasion of these pathogenic bacteria.19 20 37
gp96 Positive_regulation (promotes) of Gene_expression (homologue) of Gp96 in plasma associated with meningitis and infection
1) Confidence 0.24 Published 2010 Journal Gut Section Body Doc Link PMC2976078 Disease Relevance 0.62 Pain Relevance 0.03

General Comments

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