INT342562

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Context Info
Confidence 0.10
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 6
Disease Relevance 5.70
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
plasma 2
eosinophils 1
EOE2 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 30 49.52 Quite Low
Nerve growth factor 24 35.76 Quite Low
fibrosis 24 28.48 Quite Low
Inflammation 30 5.00 Very Low Very Low Very Low
Crohn's disease 30 5.00 Very Low Very Low Very Low
chemokine 12 5.00 Very Low Very Low Very Low
abdominal pain 6 5.00 Very Low Very Low Very Low
antagonist 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Eosinophilic Esophagitis 636 100.00 Very High Very High Very High
Apoptosis 30 96.22 Very High Very High Very High
Gastroesophageal Reflux Disease 216 90.64 High High
Food Hypersensitivity 18 76.96 Quite High
Injury 12 63.76 Quite High
Fibrosis 36 28.48 Quite Low
Disease 108 5.00 Very Low Very Low Very Low
Inflammatory Bowel Disease 30 5.00 Very Low Very Low Very Low
INFLAMMATION 30 5.00 Very Low Very Low Very Low
Rhinitis 24 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our data show that FGF, as assessed by IHC of local tissue and bFGF assessed by QT-PCR of PBMC, are upregulated in EoE.
Positive_regulation (upregulated) of EoE associated with eosinophilic esophagitis
1) Confidence 0.10 Published 2010 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2976489 Disease Relevance 0.62 Pain Relevance 0
Our data showed an increased expression of ERK in the PBMC of EoE subjects, and it is possible that, together with eotaxin, FGF enhances activation of eosinophils in EoE specifically.
Positive_regulation (activation) of EoE in eosinophils associated with eosinophilic esophagitis
2) Confidence 0.10 Published 2010 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2976489 Disease Relevance 0.67 Pain Relevance 0
EoE subjects had a 3-fold increase in Bcl-2 expression compared to treated EoE patients while caspase 8 showed a 3-fold decrease (p < 0.05) (Figure 1e).
Positive_regulation (increase) of EoE associated with eosinophilic esophagitis
3) Confidence 0.10 Published 2010 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2976489 Disease Relevance 1.02 Pain Relevance 0
Since we found bFGF and other immune indicators to be specifically increased in PBMCs of EoE subjects, we then performed fluid assays to determine whether they were present systemically in the plasma.
Positive_regulation (increased) of EoE in plasma associated with eosinophilic esophagitis
4) Confidence 0.10 Published 2010 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2976489 Disease Relevance 0.90 Pain Relevance 0
In plasma from HC subjects (n = 10), bFGF levels were low (mean 0.13 pg/mL, s.e. 0.09 pg/mL) while bFGF was significantly upregulated in EoE subjects (n = 10, mean 81.98 pg/mL, s.e. 17.23 pg/mL for EoE, p < 0.05).
Positive_regulation (upregulated) of EoE in plasma associated with eosinophilic esophagitis
5) Confidence 0.10 Published 2010 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2976489 Disease Relevance 1.36 Pain Relevance 0
Interestingly, upon examination of transcript expression of signaling pathway proteins and apoptosis-related proteins such as ERK, JNK, Bcl-2, caspase 8, and Fas, for the newly diagnosed EoE subjects, it was found that the signaling pathway transcripts of ERK but not JNK were found to be increased relative to HC, UC, CD and treated EoE (Figure 1d).
Positive_regulation (increased) of EoE associated with apoptosis and eosinophilic esophagitis
6) Confidence 0.10 Published 2010 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2976489 Disease Relevance 1.13 Pain Relevance 0

General Comments

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