INT342606

Context Info Confidence 0.08 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 1.16 Pain Relevance 0.37

cytoplasm (MMP14, VEGFA) extracellular space (VEGFA) growth (VEGFA) extracellular region (VEGFA) proteinaceous extracellular matrix (VEGFA)

MMP14 (Homo sapiens) VEGFA (Homo sapiens)

Pain Link Frequency Relevance Heat palliative 43 93.60 metalloproteinase 8 5.00

Disease Link Frequency Relevance Heat Cancer 36 99.98 Hepatocellular Cancer 58 91.60 Metastasis 24 89.00 Lifespan 8 80.00 Residual Neoplasm 3 10.16 Anaemia 1 5.00 Body Weight 1 5.00 Death 1 5.00 Dislocations 1 5.00 Thrombocytopenia 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The alteration of endostatin (a potent angiogenesis inhibitor) and MT1-MMP (an activator of MMP2) was minor, which indicated that elevated tumor VEGF and increased MMP2 activity were not directly due to endostatin and MT1-MMP, whose detailed molecular mechanism remains to be elucidated.

MT1-MMP Binding (due) of VEGF associated with cancer

1) Confidence 0.08 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2976755 Disease Relevance 1.16 Pain Relevance 0.37

General Comments

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