INT34263

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.35
First Reported 1987
Last Reported 2001
Negated 0
Speculated 0
Reported most in Abstract
Documents 8
Total Number 8
Disease Relevance 1.36
Pain Relevance 4.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitosis (Mastl) cytoskeleton (Mastl) nucleus (Mastl)
cell cycle (Mastl) cell division (Mastl) kinase activity (Mastl)
Anatomy Link Frequency
brain 2
Mastl (Mus musculus)
Pain Link Frequency Relevance Heat
tolerance 21 100.00 Very High Very High Very High
Antinociceptive 13 100.00 Very High Very High Very High
Enkephalin 2 99.32 Very High Very High Very High
agonist 1 98.78 Very High Very High Very High
opioid receptor 2 98.62 Very High Very High Very High
antinociception 9 97.94 Very High Very High Very High
Morphine 3 97.04 Very High Very High Very High
Cannabinoid receptor 2 97.04 Very High Very High Very High
antagonist 4 95.36 Very High Very High Very High
narcan 1 92.16 High High
Disease Link Frequency Relevance Heat
Ataxia 3 100.00 Very High Very High Very High
Ocular Toxicity (including Many Sub-types) 2 100.00 Very High Very High Very High
Sleep Disorders 2 100.00 Very High Very High Very High
Depression 5 87.00 High High
Catalepsy 3 74.92 Quite High
Abnormal Reflex 1 73.72 Quite High
Hypothermia 2 66.44 Quite High
Nociception 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our findings also indicate that marijuana-induced antinociception is mediated through a CB1-receptor mechanism of action and are consistent with the notion that Delta9-THC is mainly responsible for this effect.
Positive_regulation (responsible) of THC associated with antinociception
1) Confidence 0.35 Published 2001 Journal Drug Alcohol Depend Section Abstract Doc Link 11376914 Disease Relevance 0.43 Pain Relevance 0.34
We have shown previously that CBD pretreatment of mice increases brain levels of THC and have now further characterized this effect and determined whether the brain pharmacokinetics of other drugs are also affected.
Positive_regulation (increases) of THC in brain
2) Confidence 0.12 Published 2001 Journal Biochem. Pharmacol. Section Abstract Doc Link 11331071 Disease Relevance 0 Pain Relevance 0.13
CBD pretreatment of mice (30-60 min) increased brain levels of THC nearly 3-fold, whereas CBD co-administration did not.
Positive_regulation (increased) of THC in brain
3) Confidence 0.08 Published 2001 Journal Biochem. Pharmacol. Section Abstract Doc Link 11331071 Disease Relevance 0 Pain Relevance 0.18
We observed a significant increase in the ED50 for delta9-THC in antisense-, but not mismatch-treated mice, indicating an increase in tolerance to delta9-THC.
Positive_regulation (increase) of delta9-THC associated with tolerance
4) Confidence 0.03 Published 1998 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 9476987 Disease Relevance 0 Pain Relevance 0.67
We observed a significant increase in the ED50 for delta9-THC in antisense-, but not mismatch-treated mice, indicating an increase in tolerance to delta9-THC.
Positive_regulation (increase) of delta9-THC associated with tolerance
5) Confidence 0.02 Published 1998 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 9476987 Disease Relevance 0 Pain Relevance 0.67
We observed a significant increase in the ED50 for delta9-THC in antisense-, but not mismatch-treated mice, indicating an increase in tolerance to delta9-THC.
Positive_regulation (increase) of delta9-THC associated with tolerance
6) Confidence 0.02 Published 1998 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 9476987 Disease Relevance 0 Pain Relevance 0.69
As in the case of morphine or DAMGO ([D-Ala2.N-Me-Phe4,Gly-ol]enkephalin), a mu-selective opioid receptor agonist, the mixture of enkephalin-degrading enzyme inhibitors also enhanced the antinociceptive effect of delta9-THC.
Positive_regulation (enhanced) of delta9-THC associated with agonist, opioid receptor, enkephalin, antinociceptive and morphine
7) Confidence 0.02 Published 1998 Journal Neuropharmacology Section Abstract Doc Link 9680246 Disease Relevance 0 Pain Relevance 1.49
When monkeys were pretreated with delta 9-11-THC the doses of delta 9-THC required to produce ptosis, sedation, ataxia and operant suppression were increased.
Positive_regulation (increased) of 9-THC associated with ataxia, ocular toxicity (including many sub-types) and sleep disorders
8) Confidence 0.01 Published 1987 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 3033218 Disease Relevance 0.93 Pain Relevance 0.17

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox