INT34266

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.01
First Reported 1987
Last Reported 2005
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0
Pain Relevance 2.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (PRLR) plasma membrane (PRLR)
PRLR (Homo sapiens)
Pain Link Frequency Relevance Heat
Morphine 5 99.48 Very High Very High Very High
Opioid 6 99.34 Very High Very High Very High
agonist 4 99.18 Very High Very High Very High
narcan 2 97.50 Very High Very High Very High
antagonist 3 97.24 Very High Very High Very High
Dopamine 1 97.00 Very High Very High Very High
opioid receptor 13 96.92 Very High Very High Very High
Enkephalin 2 96.72 Very High Very High Very High
Delta opioid receptors 3 91.04 High High
Immobilon 2 82.32 Quite High

|}

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The agonists DADL, morphine, and DAMGO competitively inhibited bremazocine binding to the tagged delta receptor with K(I)'s of 0.9, 370, and 620 nM, respectively.
Negative_regulation (inhibited) of delta receptor Binding (binding) of associated with agonist and morphine
1) Confidence 0.01 Published 2005 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 15893587 Disease Relevance 0 Pain Relevance 0.28
Delta 9-THC also inhibited the binding of the delta opioid [3H]D-Pen2, D-Pen5-enkephalin and the opioid antagonist [3H]naloxone (Ki = 16 and 19 microM, respectively) but failed to inhibit the binding of the kappa opioid [3H]ethylketocyclazocine (after suppression of mu and delta receptor binding), the phencyclidine analog [3H]N-(1-[2-theinyl]cyclohexyl)piperidine, the dopamine antagonist [3H]spiroperidol or the muscarinic antagonist [3H]quinuclidinyl benzilate.
Negative_regulation (suppression) of delta receptor Binding (binding) of associated with dopamine, antagonist, narcan, enkephalin and opioid
2) Confidence 0.00 Published 1987 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 3033219 Disease Relevance 0 Pain Relevance 1.07
The reduction in delta receptor binding after DSLET treatment was not accompanied by significantly diminished levels of delta receptor mRNA.
Negative_regulation (reduction) of delta receptor Binding (binding) of
3) Confidence 0.00 Published 1996 Journal Neuroreport Section Abstract Doc Link 8856708 Disease Relevance 0 Pain Relevance 1.00

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox