INT34268

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Context Info
Confidence 0.47
First Reported 1987
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 14
Total Number 14
Disease Relevance 4.41
Pain Relevance 8.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (WAS) protein complex assembly (WAS) cytoplasm (WAS)
Anatomy Link Frequency
spinal 1
neuronal 1
WAS (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 55 100.00 Very High Very High Very High
Analgesic 26 100.00 Very High Very High Very High
opiate 18 100.00 Very High Very High Very High
Enkephalin 6 100.00 Very High Very High Very High
alcohol 77 99.76 Very High Very High Very High
Morphine 59 99.72 Very High Very High Very High
Cannabinoid 86 99.66 Very High Very High Very High
Opioid 19 99.44 Very High Very High Very High
Lasting pain 14 99.16 Very High Very High Very High
Cannabinoid receptor 13 99.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pain 73 100.00 Very High Very High Very High
Nociception 7 100.00 Very High Very High Very High
Wasting Syndrome 1 99.56 Very High Very High Very High
Nicotine Addiction 5 99.20 Very High Very High Very High
Muscular Spasm 3 98.68 Very High Very High Very High
Vomiting 9 98.08 Very High Very High Very High
Glaucoma 1 97.44 Very High Very High Very High
Anxiety Disorder 8 97.04 Very High Very High Very High
Infection 2 95.20 Very High Very High Very High
Hyperalgesia 11 94.84 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
THC was found alone in 60% of cases and associated with alcohol in 32%, with OR=4.6 between drivers and controls for this association.
THC Binding (associated) of associated with alcohol
1) Confidence 0.47 Published 2003 Journal Forensic Sci. Int. Section Abstract Doc Link 12742692 Disease Relevance 0.11 Pain Relevance 0.56
THC can also interact with other mood-altering medications such as Valium, librium, Xanax, seconal, Nembutal, or phenobarbital, by exaggerating their effect.
THC Binding (interact) of
2) Confidence 0.40 Published 1996 Journal PI Perspect Section Abstract Doc Link 11363969 Disease Relevance 0.59 Pain Relevance 0.12
Cannabinoids, such as Delta9-THC, are capable of inhibiting nociception, i.e., pain transmission, at least in part, by interacting with spinal Gi/Go-coupled cannabinoid receptors.
THC Binding (interacting) of in spinal associated with nociception, pain, cannabinoid receptor and cannabinoid
3) Confidence 0.35 Published 1998 Journal J. Neurosci. Section Abstract Doc Link 9412521 Disease Relevance 0.56 Pain Relevance 0.67
THC acts as a substitute ligand to the 7TM receptor site of AEA.
THC Binding (ligand) of
4) Confidence 0.34 Published 2002 Journal Prog. Neuropsychopharmacol. Biol. Psychiatry Section Abstract Doc Link 12188105 Disease Relevance 0.15 Pain Relevance 0.22
Among affective responses, although neither morphine nor Delta(9)-THC had a significant effect, there was a positive analgesic interaction between the two (p = 0.012), indicating that the combination had a synergistic affective analgesic effect.
THC Binding (interaction) of associated with analgesic and morphine
5) Confidence 0.30 Published 2006 Journal Eur. J. Pharmacol. Section Abstract Doc Link 16375890 Disease Relevance 0.38 Pain Relevance 1.50
The primary active constituent of marijuana, delta9-tetrahydrohydrocannabinol (THC), binds to specific G-protein-coupled receptors.
THC Binding (binds) of
6) Confidence 0.27 Published 2003 Journal Crit Rev Neurobiol Section Abstract Doc Link 14977366 Disease Relevance 0.08 Pain Relevance 0.54
Interaction between naltrexone and oral THC in heavy marijuana smokers.
THC Binding (Interaction) of associated with nicotine addiction
7) Confidence 0.26 Published 2003 Journal Psychopharmacology (Berl.) Section Title Doc Link 12491025 Disease Relevance 0.10 Pain Relevance 0.19
These findings suggest that ajulemic acid reduces abnormal pain sensations associated with chronic pain without producing the motor side effects associated with THC and other non-selective cannabinoid receptor agonists.
THC Binding (associated) of associated with pain, cannabinoid receptor, lasting pain and agonist
8) Confidence 0.23 Published 2005 Journal Neurosci. Lett. Section Abstract Doc Link 15925096 Disease Relevance 0.91 Pain Relevance 1.05
Delta(9)-THC binds to and activates two known cannabinoid receptors found in mammalian tissue, CB1 and CB2.
THC Binding (binds) of associated with cannabinoid receptor
9) Confidence 0.16 Published 2001 Journal Pharmacol. Ther. Section Abstract Doc Link 11448725 Disease Relevance 0.69 Pain Relevance 0.37
Although morphine is not considered to be a psychedelic, and ibogaine, THC, and salvinorin A are not considered to be “classical hallucinogens,” these four compounds are included because they provide insights into additional receptor systems (salvinorin A – ?
THC Binding (ibogaine) of associated with morphine
10) Confidence 0.09 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2814854 Disease Relevance 0 Pain Relevance 0.48
Among the noteworthy interactions with opiates and the endorphin/enkephalin system, THC has been shown to stimulate beta-endorphin production (Manzanares et al 1998), may allow opiate sparing in clinical application (Cichewicz et al 1999), prevents development of tolerance to and withdrawal from opiates (Cichewicz and Welch 2003), and rekindles opiate analgesia after a prior dosage has worn off (Cichewicz and McCarthy 2003).
THC Binding (interactions) of associated with tolerance, enkephalin, opiate, withdrawal and analgesia
11) Confidence 0.09 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2503660 Disease Relevance 0.67 Pain Relevance 1.69
Therefore, chronic daily THC use was found to be associated with distinct topographic qEEG features.
THC Binding (associated) of
12) Confidence 0.02 Published 2008 Journal Appl Psychophysiol Biofeedback Section Body Doc Link PMC2259255 Disease Relevance 0.17 Pain Relevance 0.03
Delta 9-THC also inhibited the binding of the delta opioid [3H]D-Pen2, D-Pen5-enkephalin and the opioid antagonist [3H]naloxone (Ki = 16 and 19 microM, respectively) but failed to inhibit the binding of the kappa opioid [3H]ethylketocyclazocine (after suppression of mu and delta receptor binding), the phencyclidine analog [3H]N-(1-[2-theinyl]cyclohexyl)piperidine, the dopamine antagonist [3H]spiroperidol or the muscarinic antagonist [3H]quinuclidinyl benzilate.
9-THC Binding (binding) of associated with dopamine, antagonist, narcan, enkephalin and opioid
13) Confidence 0.01 Published 1987 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 3033219 Disease Relevance 0 Pain Relevance 1.01
The interaction of delta 9-tetrahydrocannabinol (delta 9-THC) and related cannabinoids with opioid receptors of neuronal membranes has been investigated.
9-THC Binding (interaction) of in neuronal associated with cannabinoid and opioid receptor
14) Confidence 0.01 Published 1987 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 3033219 Disease Relevance 0 Pain Relevance 0.26

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