INT342689

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Context Info
Confidence 0.03
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.24
Pain Relevance 0.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Ptger4, Prkaca) mitochondrion (Prkaca) Golgi apparatus (Prkaca)
protein complex (Prkaca) cytoplasm (Prkaca) signal transducer activity (Ptger4)
Anatomy Link Frequency
PGE2 1
Ptger4 (Mus musculus)
Prkaca (Mus musculus)
Pain Link Frequency Relevance Heat
Pain 8 95.76 Very High Very High Very High
Nerve growth factor 1 91.40 High High
bradykinin 1 90.56 High High
adenocard 1 89.56 High High
Inflammation 1 86.68 High High
Sciatic nerve 4 79.20 Quite High
unmyelinated 4 78.12 Quite High
tetrodotoxin 3 62.64 Quite High
sodium channel 16 39.64 Quite Low
Lasting pain 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pain 12 95.76 Very High Very High Very High
INFLAMMATION 1 86.68 High High
Targeted Disruption 5 59.64 Quite High
Nociception 4 5.00 Very Low Very Low Very Low
Neuropathic Pain 3 5.00 Very Low Very Low Very Low
Diabetic Neuropathy 1 5.00 Very Low Very Low Very Low
Nerve Compression Syndromes 1 5.00 Very Low Very Low Very Low
Herpes Simplex Virus 1 5.00 Very Low Very Low Very Low
Injury 1 5.00 Very Low Very Low Very Low
Inflammatory Pain 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Among these compounds, PGE2, a derivate of arachidonic acid, binds to its receptors, EP2 and EP4, which in turn activate intracellular Protein kinase A (PKA) (reviewed in Refs. [31,25]).
EP4 Positive_regulation (activate) of PKA in PGE2
1) Confidence 0.03 Published 2010 Journal Neuroscience Letters Section Body Doc Link PMC2977848 Disease Relevance 0.24 Pain Relevance 0.51

General Comments

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