INT342696

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Context Info
Confidence 0.65
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.19
Pain Relevance 0.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Park2) Golgi apparatus (Park2) endoplasmic reticulum (Park2)
intracellular (Park2) protein complex (Park2) ligase activity (Park2)
Park2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
midbrain 52 91.12 High High
Glutamate 20 5.00 Very Low Very Low Very Low
Ventral tegmentum 14 5.00 Very Low Very Low Very Low
Inflammation 12 5.00 Very Low Very Low Very Low
monoamine 10 5.00 Very Low Very Low Very Low
Locus ceruleus 6 5.00 Very Low Very Low Very Low
Substantia nigra 6 5.00 Very Low Very Low Very Low
cytokine 6 5.00 Very Low Very Low Very Low
antagonist 4 5.00 Very Low Very Low Very Low
Neurotransmitter 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 176 98.80 Very High Very High Very High
Parkinson's Disease 84 98.28 Very High Very High Very High
Death 10 61.36 Quite High
Pressure And Volume Under Development 2 49.20 Quite Low
Aging 30 5.00 Very Low Very Low Very Low
Stress 22 5.00 Very Low Very Low Very Low
INFLAMMATION 14 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 12 5.00 Very Low Very Low Very Low
Toxicity 10 5.00 Very Low Very Low Very Low
Dementia 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Parkin is a ubiquitously expressed protein, present in different subcellular fractions (Shimura et al., 1999), with several domains for protein–protein interactions and E3 ubiquitin protein ligase activity (Zhang et al., 2000).
Gene_expression (expressed) of Parkin
1) Confidence 0.65 Published 2010 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2978035 Disease Relevance 0.57 Pain Relevance 0.04
Convincing evidence for the involvement of mitochondrial dysfunction in the pathogenesis of PD also arises from the discovery of mutations in genes which encode the Parkin, PINK1, DJ-1, ?
Gene_expression (encode) of Parkin associated with parkinson's disease and disease
2) Confidence 0.65 Published 2010 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2978035 Disease Relevance 0.61 Pain Relevance 0.05

General Comments

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