INT342722

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Context Info
Confidence 0.41
First Reported 2010
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.81
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Lrrk2) plasma membrane (Lrrk2) intracellular (Lrrk2)
kinase activity (Lrrk2) cytoplasm (Lrrk2)
Lrrk2 (Mus musculus)
Pain Link Frequency Relevance Heat
Substantia nigra 4 68.28 Quite High
Inflammation 55 50.00 Quite Low
Dopamine 62 46.04 Quite Low
cytokine 80 26.44 Quite Low
Central nervous system 24 23.96 Low Low
midbrain 31 5.00 Very Low Very Low Very Low
Glutamate 10 5.00 Very Low Very Low Very Low
monoamine 7 5.00 Very Low Very Low Very Low
Ventral tegmentum 7 5.00 Very Low Very Low Very Low
Locus ceruleus 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 196 99.80 Very High Very High Very High
Apoptosis 7 98.64 Very High Very High Very High
Toxicity 6 86.72 High High
Parkinson's Disease 62 84.48 Quite High
Neurodegenerative Disease 23 55.04 Quite High
INFLAMMATION 74 50.00 Quite Low
Parkinsonian Disorders 4 41.44 Quite Low
Arrhythmias 2 Under Development 1 37.04 Quite Low
Death 14 14.32 Low Low
Congenital Anomalies 2 8.04 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although the involvement of mitochondria in the pathogenesis of LRRK2 mutant-associated PD remains unclear, the facts that LRRK2 partially colocalizes with mitochondrial markers (Biskup et al., 2006), and that overexpression of mutant LRRK2 proteins induces Apaf1 dependent apoptosis (Iaccarino et al., 2007), suggest that LRRK2 mutations can compromise mitochondrial function.
Gene_expression (overexpression) of LRRK2 associated with apoptosis and disease
1) Confidence 0.41 Published 2010 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2978035 Disease Relevance 0.73 Pain Relevance 0.03
Indeed, there is a very low penetrance of LRRK2 heterozygotic carriers that actually express the PD phenotype; yet, a significant proportion of PD patients carry a LRRK2 mutation, suggesting that such genes might be seen as susceptibility factors [32].
Gene_expression (express) of LRRK2 associated with disease
2) Confidence 0.30 Published 2011 Journal Parkinson's Disease Section Body Doc Link PMC3018622 Disease Relevance 1.08 Pain Relevance 0

General Comments

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