INT342732

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Context Info
Confidence 0.00
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.72
Pain Relevance 0.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
midbrain 1
Arrd1 (Mus musculus)
da (Mus musculus)
Pain Link Frequency Relevance Heat
midbrain 26 98.66 Very High Very High Very High
Glutamate 10 5.00 Very Low Very Low Very Low
Ventral tegmentum 7 5.00 Very Low Very Low Very Low
Inflammation 6 5.00 Very Low Very Low Very Low
monoamine 5 5.00 Very Low Very Low Very Low
Locus ceruleus 3 5.00 Very Low Very Low Very Low
Substantia nigra 3 5.00 Very Low Very Low Very Low
cytokine 3 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
Neurotransmitter 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Aging 15 99.56 Very High Very High Very High
Disease 88 86.36 High High
Stress 11 63.76 Quite High
Parkinson's Disease 42 47.96 Quite Low
Attention Deficit Hyperactivity Disorder 1 22.96 Low Low
INFLAMMATION 7 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 6 5.00 Very Low Very Low Very Low
Toxicity 5 5.00 Very Low Very Low Very Low
Death 5 5.00 Very Low Very Low Very Low
Dementia 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, this idea is challenged by other studies performed on monkeys (Irwin et al., 1994; McCormack et al., 2004; Collier et al., 2007) and humans (Kubis et al., 2000) according to which the number of midbrain DA-cells does not change during normal aging, suggesting that the age-related loss of striatal DA levels (Kish et al., 1992; Haycock et al., 2003) is due to a progressive chemical and functional decline rather than to degeneration.
age-related Negative_regulation (loss) of DA in midbrain associated with aging and midbrain
1) Confidence 0.00 Published 2010 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2978035 Disease Relevance 0.72 Pain Relevance 0.16

General Comments

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