INT342733

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.10
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.74
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

intracellular (Lrrk2, Apaf1) cytoplasm (Lrrk2, Apaf1) cytosol (Apaf1)
mitochondrion (Lrrk2) Golgi apparatus (Apaf1) nucleus (Apaf1)
Lrrk2 (Mus musculus)
Apaf1 (Mus musculus)
Pain Link Frequency Relevance Heat
Substantia nigra 3 68.28 Quite High
midbrain 26 5.00 Very Low Very Low Very Low
Glutamate 10 5.00 Very Low Very Low Very Low
Ventral tegmentum 7 5.00 Very Low Very Low Very Low
Inflammation 6 5.00 Very Low Very Low Very Low
monoamine 5 5.00 Very Low Very Low Very Low
Locus ceruleus 3 5.00 Very Low Very Low Very Low
cytokine 3 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
Neurotransmitter 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 2 99.56 Very High Very High Very High
Disease 88 97.60 Very High Very High Very High
Toxicity 5 86.72 High High
Parkinson's Disease 42 86.32 High High
Neurodegenerative Disease 6 56.88 Quite High
Arrhythmias 2 Under Development 1 37.04 Quite Low
Congenital Anomalies 2 8.04 Low Low
Aging 15 5.00 Very Low Very Low Very Low
Stress 11 5.00 Very Low Very Low Very Low
INFLAMMATION 7 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although the involvement of mitochondria in the pathogenesis of LRRK2 mutant-associated PD remains unclear, the facts that LRRK2 partially colocalizes with mitochondrial markers (Biskup et al., 2006), and that overexpression of mutant LRRK2 proteins induces Apaf1 dependent apoptosis (Iaccarino et al., 2007), suggest that LRRK2 mutations can compromise mitochondrial function.
Gene_expression (overexpression) of LRRK2 Positive_regulation (induces) of Apaf1 associated with apoptosis and disease
1) Confidence 0.10 Published 2010 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2978035 Disease Relevance 0.74 Pain Relevance 0.03

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox