INT342733
From wiki-pain
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Sentences Mentioned In
Key: | Protein | Mutation | Event | Anatomy | Negation | Speculation | Pain term | Disease term |
Although the involvement of mitochondria in the pathogenesis of LRRK2 mutant-associated PD remains unclear, the facts that LRRK2 partially colocalizes with mitochondrial markers (Biskup et al., 2006), and that overexpression of mutant LRRK2 proteins induces Apaf1 dependent apoptosis (Iaccarino et al., 2007), suggest that LRRK2 mutations can compromise mitochondrial function. | |||||||||||||||
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General Comments
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