INT342733

Context Info Confidence 0.10 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.74 Pain Relevance 0.03

intracellular (Lrrk2, Apaf1) cytoplasm (Lrrk2, Apaf1) cytosol (Apaf1) mitochondrion (Lrrk2) Golgi apparatus (Apaf1) nucleus (Apaf1)

Lrrk2 (Mus musculus) Apaf1 (Mus musculus)

Pain Link Frequency Relevance Heat Substantia nigra 3 68.28 midbrain 26 5.00 Glutamate 10 5.00 Ventral tegmentum 7 5.00 Inflammation 6 5.00 monoamine 5 5.00 Locus ceruleus 3 5.00 cytokine 3 5.00 antagonist 2 5.00 Neurotransmitter 2 5.00

Disease Link Frequency Relevance Heat Apoptosis 2 99.56 Disease 88 97.60 Toxicity 5 86.72 Parkinson's Disease 42 86.32 Neurodegenerative Disease 6 56.88 Arrhythmias 2 Under Development 1 37.04 Congenital Anomalies 2 8.04 Aging 15 5.00 Stress 11 5.00 INFLAMMATION 7 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Although the involvement of mitochondria in the pathogenesis of LRRK2 mutant-associated PD remains unclear, the facts that LRRK2 partially colocalizes with mitochondrial markers (Biskup et al., 2006), and that overexpression of mutant LRRK2 proteins induces Apaf1 dependent apoptosis (Iaccarino et al., 2007), suggest that LRRK2 mutations can compromise mitochondrial function.

Gene_expression (overexpression) of LRRK2 Positive_regulation (induces) of Apaf1 associated with apoptosis and disease

1) Confidence 0.10 Published 2010 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2978035 Disease Relevance 0.74 Pain Relevance 0.03

General Comments

This test has worked.