INT342736

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Context Info
Confidence 0.29
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.58
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Pink1, HTRA2) response to stress (Pink1, HTRA2) cytosol (Pink1, HTRA2)
unfolded protein binding (HTRA2) endoplasmic reticulum (HTRA2) mitochondrion organization (HTRA2)
Pink1 (Mus musculus)
HTRA2 (Homo sapiens)
Pain Link Frequency Relevance Heat
midbrain 26 22.16 Low Low
Glutamate 10 5.00 Very Low Very Low Very Low
Ventral tegmentum 7 5.00 Very Low Very Low Very Low
Inflammation 6 5.00 Very Low Very Low Very Low
monoamine 5 5.00 Very Low Very Low Very Low
Locus ceruleus 3 5.00 Very Low Very Low Very Low
Substantia nigra 3 5.00 Very Low Very Low Very Low
cytokine 3 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
Neurotransmitter 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 88 95.64 Very High Very High Very High
Targeted Disruption 2 81.60 Quite High
Parkinson's Disease 42 79.84 Quite High
Pressure And Volume Under Development 1 71.60 Quite High
Apoptosis 2 69.92 Quite High
Death 5 65.40 Quite High
Stress 11 23.52 Low Low
Aging 15 5.00 Very Low Very Low Very Low
INFLAMMATION 7 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
PINK1 regulates the activity and phosphorylation of TRAP1 (TNF-receptor-associated protein 1), a protein which acts as a chaperone to prevent protein misfolding (Pridgeon et al., 2007), HtrA2/Omi, which acts as a protease involved in the degradation of misfolded proteins (Alnemri, 2007), and Parkin.
PINK1 Positive_regulation (regulates) of Phosphorylation (phosphorylation) of Omi
1) Confidence 0.29 Published 2010 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2978035 Disease Relevance 0.58 Pain Relevance 0

General Comments

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