INT342744

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Context Info
Confidence 0.02
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.37
Pain Relevance 0.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Ddc, Trh) extracellular region (Trh) lyase activity (Ddc)
plasma membrane (Trh) nucleus (Trh) intracellular (Ddc)
Anatomy Link Frequency
striatum 1
Ddc (Rattus norvegicus)
Trh (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 47 99.68 Very High Very High Very High
Substantia nigra 9 74.12 Quite High
Opioid receptor 1 7 62.08 Quite High
dopamine receptor 2 5.00 Very Low Very Low Very Low
ketamine 1 5.00 Very Low Very Low Very Low
midbrain 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
antagonist 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Dyskinesias 34 89.60 High High
Movement Disorders 1 78.32 Quite High
Disease 21 64.88 Quite High
Parkinson's Disease 6 50.00 Quite Low
Thyroid Disease 2 28.96 Quite Low
Hyperkinesis 5 25.28 Quite Low
Hyperthyroidism 2 15.28 Low Low
Tremor 2 10.08 Low Low
Congenital Anomalies 3 5.00 Very Low Very Low Very Low
Dystonia 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This result is particularly striking, as it suggests that the TRH up-regulation induced by L-DOPA in the dopamine-depleted striatum differentially affects subcircuits within the direct, indirect and striosomal pathways.
L-DOPA Regulation (regulation) of TRH in striatum associated with dopamine
1) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2978093 Disease Relevance 0.37 Pain Relevance 0.18

General Comments

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