INT342803

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Context Info
Confidence 0.30
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 0.33
Pain Relevance 2.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Cyp19a1) endoplasmic reticulum (Cyp19a1) cytoplasm (Cyp19a1)
Anatomy Link Frequency
brain 3
gonads 1
Cyp19a1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 212 99.48 Very High Very High Very High
Analgesic 8 90.24 High High
Lasting pain 4 88.28 High High
Opioid 24 81.00 Quite High
Pain 76 75.00 Quite High
opiate 8 5.00 Very Low Very Low Very Low
Hippocampus 8 5.00 Very Low Very Low Very Low
opioid receptor 8 5.00 Very Low Very Low Very Low
Endogenous opioid 4 5.00 Very Low Very Low Very Low
Codeine 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pain 80 88.28 High High
Cognitive Disorder 12 5.00 Very Low Very Low Very Low
Stress 8 5.00 Very Low Very Low Very Low
Anaemia 4 5.00 Very Low Very Low Very Low
Death 4 5.00 Very Low Very Low Very Low
Fatigue 4 5.00 Very Low Very Low Very Low
Inflammatory Pain 4 5.00 Very Low Very Low Very Low
Reprotox - General 2 4 5.00 Very Low Very Low Very Low
Convulsion 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the morphine-treated rats, there were increases of 5-alpha reductase mRNA expression in the liver and aromatase mRNA expression in the brain and gonads.
Positive_regulation (increases) of Transcription (expression) of aromatase in brain associated with morphine
1) Confidence 0.30 Published 2010 Journal Mol Pain Section Abstract Doc Link PMC2978140 Disease Relevance 0.16 Pain Relevance 1.04
mRNA levels for 5-alpha reductase and P450-aromatase (Ct) were normalized to cyclophilin by subtracting the Ct value of the reference gene (cyclophilin) from the Ct value of the samples (?
Positive_regulation (for) of Transcription (levels) of P450-aromatase
2) Confidence 0.28 Published 2010 Journal Mol Pain Section Body Doc Link PMC2978140 Disease Relevance 0 Pain Relevance 0
mRNA levels for 5-alpha reductase and P450-aromatase (Ct) were normalized to cyclophilin by subtracting the Ct value of the reference gene (cyclophilin) from the Ct value of the samples (?
Positive_regulation (normalized) of Transcription (levels) of P450-aromatase
3) Confidence 0.28 Published 2010 Journal Mol Pain Section Body Doc Link PMC2978140 Disease Relevance 0 Pain Relevance 0
In the morphine-treated rats, there were increases of 5-alpha reductase mRNA expression in the liver and aromatase mRNA expression in the brain and gonads.
Positive_regulation (increases) of in gonads Transcription (expression) of aromatase in brain associated with morphine
4) Confidence 0.10 Published 2010 Journal Mol Pain Section Abstract Doc Link PMC2978140 Disease Relevance 0.16 Pain Relevance 1.04

General Comments

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