INT342886

Context Info Confidence 0.02 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.66 Pain Relevance 0.05

signal transduction (C3, CD40) extracellular region (C3, CD40) extracellular space (C3) plasma membrane (CD40) enzyme binding (CD40) protein complex assembly (CD40)

Anatomy Link Frequency lymphocyte 1 C3 (Homo sapiens) CD40 (Homo sapiens)

Pain Link Frequency Relevance Heat adenocard 1 99.72 psoriasis 3 38.04 Inflammation 13 35.20 corticosteroid 3 5.00 Analgesic 1 5.00 cINOD 1 5.00 Pain 1 5.00 Inflammatory response 1 5.00 antagonist 1 5.00

Disease Link Frequency Relevance Heat Neutrophil Disorders 1 97.00 Syndrome 7 96.14 Immunodeficiency 3 95.74 Granuloma 1 75.20 Cutaneous Tuberculosis 2 67.04 Ulcers 1 63.40 Hepatitis 1 58.12 Bordatella Infection 1 55.56 Anaerobic Bacterial Infections 1 55.00 Osteomyelitis 30 50.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Possibilities of combined immunodeficiency, hyper IgM syndrome types I/III, chronic granulomatous disease, IL-12/interferon-gamma pathway defects were excluded: Immunoglobulin G-M-A serum concentrations, lymphocyte subsets, expression of CD40 on B cells, CD40 ligand on active T cells, complement levels (C3, C4), adenosine deaminase level, phagoburst test, expression of CD119 (interferon-gamma receptor) and IL-12 receptor ?

C3 Binding (ligand) of CD40 in lymphocyte associated with adenocard, syndrome, neutrophil disorders and immunodeficiency

1) Confidence 0.02 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2978228 Disease Relevance 0.66 Pain Relevance 0.05

General Comments

This test has worked.