INT342932

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Context Info
Confidence 0.10
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.09
Pain Relevance 0.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

isomerase activity (Renbp)
Anatomy Link Frequency
extracellular matrix 2
Renbp (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cytokine 1 99.76 Very High Very High Very High
Inflammation 4 97.92 Very High Very High Very High
carbamazepine 2 5.00 Very Low Very Low Very Low
member 8 1 5.00 Very Low Very Low Very Low
ketamine 1 5.00 Very Low Very Low Very Low
withdrawal 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
antiepileptic Drug 1 5.00 Very Low Very Low Very Low
Bile 1 5.00 Very Low Very Low Very Low
Paracetamol 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Vasculitis 5 98.28 Very High Very High Very High
Atherosclerosis 9 82.20 Quite High
Hyperplasia 6 79.72 Quite High
Aging 23 78.44 Quite High
Diabetes Mellitus 22 77.52 Quite High
Injury 23 74.64 Quite High
Pathologic Constriction 1 70.92 Quite High
Hyperglycemia 2 54.60 Quite High
Cardiovascular Disease 3 50.72 Quite High
INFLAMMATION 1 41.52 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
AGE-mediated cross-link formation in proteins such as collagen may result not only in stiffening of the arteries, but also in increased extracellular matrix formation and increased vascular inflammation, which results in increased risk of neointimal proliferation.7)19-21) AGE accumulation and formation of cross links are associated with increased proinflammatory cytokine levels and increased expression of AGE receptors (RAGEs), resulting in increased vascular inflammation.16)21)22)
Positive_regulation (increased) of Gene_expression (expression) of AGE in extracellular matrix associated with inflammation, vasculitis and cytokine
1) Confidence 0.10 Published 2010 Journal Korean Circulation Journal Section Body Doc Link PMC2978295 Disease Relevance 1.01 Pain Relevance 0.15
Igf-2 exhibits high expression at 2 weeks (100- to 500-fold change above average for female and male, respectively) followed by relatively low and constant expression at the remaining age groups.
Positive_regulation (followed) of Gene_expression (expression) of age
2) Confidence 0.09 Published 2010 Journal BMC Genomics Section Body Doc Link PMC3012673 Disease Relevance 0.08 Pain Relevance 0

General Comments

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