INT342933

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Context Info
Confidence 0.09
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 2.42
Pain Relevance 0.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

isomerase activity (Renbp)
Anatomy Link Frequency
extracellular matrix 3
connective tissue 1
Renbp (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 12 56.92 Quite High
cytokine 3 5.00 Very Low Very Low Very Low
ketamine 3 5.00 Very Low Very Low Very Low
withdrawal 3 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
imagery 3 5.00 Very Low Very Low Very Low
carbamazepine 2 5.00 Very Low Very Low Very Low
member 8 1 5.00 Very Low Very Low Very Low
antiepileptic Drug 1 5.00 Very Low Very Low Very Low
Bile 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Neointima 18 100.00 Very High Very High Very High
Hyperplasia 16 100.00 Very High Very High Very High
Diabetes Mellitus 66 93.12 High High
Injury 63 84.64 Quite High
Vasculitis 15 56.92 Quite High
Atherosclerosis 27 55.04 Quite High
Repression 3 38.72 Quite Low
Aging 25 5.00 Very Low Very Low Very Low
Stress 13 5.00 Very Low Very Low Very Low
Cardiovascular Disease 9 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This in vivo study shows that expression of AGE receptors and neointima hyperplasia are significantly suppressed in balloon-injured rats treated with alagebrium.


Negative_regulation (suppressed) of Gene_expression (expression) of AGE associated with neointima and hyperplasia
1) Confidence 0.09 Published 2010 Journal Korean Circulation Journal Section Abstract Doc Link PMC2978295 Disease Relevance 0.77 Pain Relevance 0.03
The cellular mechanisms of AGE-induced connective tissue and extracellular matrix expression were decreased in the alagebrium-treated group.
Negative_regulation (decreased) of Gene_expression (expression) of AGE in extracellular matrix
2) Confidence 0.08 Published 2010 Journal Korean Circulation Journal Section Abstract Doc Link PMC2978295 Disease Relevance 0.83 Pain Relevance 0.03
Cyp1a2, a notable xenobiotic and drug metabolizer and known target of Ahr, exhibited roughly parallel expression between sexes with maximum relative expression (~1.5 fold) peaking around 6 to 8 weeks followed by declining expression with age.
Negative_regulation (declining) of Gene_expression (expression) of age
3) Confidence 0.08 Published 2010 Journal BMC Genomics Section Body Doc Link PMC3012673 Disease Relevance 0 Pain Relevance 0
The cellular mechanisms of AGE-induced connective tissue and extracellular matrix expression were decreased in the alagebrium-treated group.
Negative_regulation (decreased) of in connective tissue Gene_expression (expression) of AGE in extracellular matrix
4) Confidence 0.03 Published 2010 Journal Korean Circulation Journal Section Abstract Doc Link PMC2978295 Disease Relevance 0.83 Pain Relevance 0.03

General Comments

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