INT34294

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Context Info
Confidence 0.16
First Reported 1984
Last Reported 1987
Negated 0
Speculated 1
Reported most in Abstract
Documents 1
Total Number 3
Disease Relevance 0.43
Pain Relevance 3.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Penk, Crh) extracellular space (Crh) response to stress (Crh)
cytoplasm (Crh)
Anatomy Link Frequency
plasma 2
Penk (Rattus norvegicus)
Crh (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Enkephalin 8 100.00 Very High Very High Very High
Morphine 16 99.96 Very High Very High Very High
Opioid 6 97.72 Very High Very High Very High
narcan 6 97.28 Very High Very High Very High
Analgesic 2 92.20 High High
tolerance 2 91.52 High High
opiate 3 87.72 High High
Disease Link Frequency Relevance Heat
Stress 5 95.00 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
DALA and Met-enkephalin seemed to stimulate CRF release from the median eminence to increase plasma ACTH, as the CRF concentration in the median eminence area was reduced after injection in these stressed rats.
Met-enkephalin Spec (seemed) Positive_regulation (stimulate) of Localization (release) of CRF in plasma associated with enkephalin
1) Confidence 0.16 Published 1987 Journal Peptides Section Abstract Doc Link 3033617 Disease Relevance 0.10 Pain Relevance 0.27
However, morphine, met-enkephalin and leu-enkephalin stimulated the secretion of CRF by hypothalami and their effects were competitively antagonized by naloxone.
leu-enkephalin Positive_regulation (stimulated) of Localization (secretion) of CRF associated with narcan, enkephalin and morphine
2) Confidence 0.15 Published 1984 Journal Neuroendocrinology Section Abstract Doc Link 6328347 Disease Relevance 0.17 Pain Relevance 1.46
However, morphine, met-enkephalin and leu-enkephalin stimulated the secretion of CRF by hypothalami and their effects were competitively antagonized by naloxone.
met-enkephalin Positive_regulation (stimulated) of Localization (secretion) of CRF associated with narcan, enkephalin and morphine
3) Confidence 0.15 Published 1984 Journal Neuroendocrinology Section Abstract Doc Link 6328347 Disease Relevance 0.17 Pain Relevance 1.46

General Comments

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