INT342955

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Context Info
Confidence 0.02
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.37
Pain Relevance 0.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (SPTBN1) nucleolus (SPTBN1) plasma membrane (SPTBN1)
nucleus (SPTBN1) cytoplasm (SPTBN1)
SPTBN1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 6 93.60 High High
ischemia 6 5.00 Very Low Very Low Very Low
addiction 3 5.00 Very Low Very Low Very Low
tolerance 3 5.00 Very Low Very Low Very Low
imagery 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pain 6 93.60 High High
Autolysis 15 72.52 Quite High
Muscular Dystrophy 6 5.00 Very Low Very Low Very Low
Disease 6 5.00 Very Low Very Low Very Low
Brain Hemorrhage 3 5.00 Very Low Very Low Very Low
Embryonic Lethality 3 5.00 Very Low Very Low Very Low
Targeted Disruption 3 5.00 Very Low Very Low Very Low
Apoptosis 3 5.00 Very Low Very Low Very Low
Death 3 5.00 Very Low Very Low Very Low
Cv Unclassified Under Development 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Several substrates of calpain are aggressively proteolyzed under pathological conditions, e.g., in neurodegenerating processes, fodrin is proteolyzed by calpain.
Protein_catabolism (proteolyzed) of fodrin
1) Confidence 0.02 Published 2007 Journal Biotechnology Journal Section Abstract Doc Link PMC2978325 Disease Relevance 0 Pain Relevance 0
This indicates that fodrin proteolysis by p94 did not change the total amount of fodrin.
Protein_catabolism (proteolysis) of fodrin
2) Confidence 0.02 Published 2007 Journal Biotechnology Journal Section Body Doc Link PMC2978325 Disease Relevance 0.17 Pain Relevance 0.09
This quantitative information, which is hard to obtain solely by Western blot analysis (Fig. 5B, anti-fodrin), suggests that limited proteolysis of fodrin by p94 does not cause immediate degradation of fodrin fragments.
Protein_catabolism (degradation) of fodrin
3) Confidence 0.02 Published 2007 Journal Biotechnology Journal Section Body Doc Link PMC2978325 Disease Relevance 0.20 Pain Relevance 0.08

General Comments

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