INT342957

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Context Info
Confidence 0.43
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.18
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

intracellular (CAPN3) protein complex assembly (CAPN3) protein complex (CAPN3)
cytoplasm (CAPN3) signal transducer activity (CAPN3) cytosol (CAPN3)
CAPN3 (Homo sapiens)
Pain Link Frequency Relevance Heat
ischemia 4 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low
addiction 2 5.00 Very Low Very Low Very Low
tolerance 2 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Autolysis 10 99.56 Very High Very High Very High
Pain 4 5.00 Very Low Very Low Very Low
Muscular Dystrophy 4 5.00 Very Low Very Low Very Low
Disease 4 5.00 Very Low Very Low Very Low
Brain Hemorrhage 2 5.00 Very Low Very Low Very Low
Embryonic Lethality 2 5.00 Very Low Very Low Very Low
Targeted Disruption 2 5.00 Very Low Very Low Very Low
Apoptosis 2 5.00 Very Low Very Low Very Low
Death 2 5.00 Very Low Very Low Very Low
Cv Unclassified Under Development 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Similar decreases of all five peptides detected for WT p94 indicate that upon autolysis, different autolyzed fragments of WT p94 concurrently become more susceptible to subsequent degradation than unau-tolyzed p94 protein.
Positive_regulation (fragments) of p94 associated with autolysis
1) Confidence 0.43 Published 2007 Journal Biotechnology Journal Section Body Doc Link PMC2978325 Disease Relevance 0.10 Pain Relevance 0
This large difference of detected relative WT quantity suggests that most of identified peptides for WT p94 by the iTRAQT™ method are derived from extensively autolyzed fragments of p94 that could not be detected by Western blot analysis due to small molecular mass and heterogeneity of the autolyzed fragments (Fig. 5D).
Positive_regulation (peptides) of p94
2) Confidence 0.43 Published 2007 Journal Biotechnology Journal Section Body Doc Link PMC2978325 Disease Relevance 0.08 Pain Relevance 0

General Comments

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