INT342958

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Context Info
Confidence 0.69
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 0.66
Pain Relevance 0.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

intracellular (CAPN3) protein complex assembly (CAPN3) protein complex (CAPN3)
cytoplasm (CAPN3) signal transducer activity (CAPN3) cytosol (CAPN3)
Anatomy Link Frequency
skeletal muscle cells 4
skeletal muscle 2
CAPN3 (Homo sapiens)
Pain Link Frequency Relevance Heat
imagery 5 94.40 High High
Pain 10 84.40 Quite High
ischemia 10 5.00 Very Low Very Low Very Low
addiction 5 5.00 Very Low Very Low Very Low
tolerance 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Autolysis 25 100.00 Very High Very High Very High
Targeted Disruption 5 99.88 Very High Very High Very High
Pain 10 84.40 Quite High
Muscular Dystrophy 10 5.00 Very Low Very Low Very Low
Disease 10 5.00 Very Low Very Low Very Low
Brain Hemorrhage 5 5.00 Very Low Very Low Very Low
Embryonic Lethality 5 5.00 Very Low Very Low Very Low
Apoptosis 5 5.00 Very Low Very Low Very Low
Death 5 5.00 Very Low Very Low Very Low
Cv Unclassified Under Development 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is particularly important to distinguish direct p94 substrates from those proteolyzed by other proteases activated by overexpression of p94.
Positive_regulation (overexpression) of Gene_expression (overexpression) of p94
1) Confidence 0.69 Published 2007 Journal Biotechnology Journal Section Body Doc Link PMC2978325 Disease Relevance 0.07 Pain Relevance 0
In COS7 cells, overexpressed p94 disappears very rapidly because of its autolytic activity (see below) [26] and simultaneously causes specific proteolysis of other proteins such as calpastatin and fodrin [17].
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of p94
2) Confidence 0.69 Published 2007 Journal Biotechnology Journal Section Body Doc Link PMC2978325 Disease Relevance 0 Pain Relevance 0.05
This was probably caused in part by much less efficient protein proteolysis by p94 than p94 autolysis, which could be because of that COS7 cells but not skeletal muscle cells were used.
Positive_regulation (caused) of Gene_expression (autolysis) of p94 in skeletal muscle cells associated with autolysis
3) Confidence 0.50 Published 2007 Journal Biotechnology Journal Section Body Doc Link PMC2978325 Disease Relevance 0.25 Pain Relevance 0.15
This was probably caused in part by much less efficient protein proteolysis by p94 than p94 autolysis, which could be because of that COS7 cells but not skeletal muscle cells were used.
Positive_regulation (caused) of Gene_expression (autolysis) of p94 in skeletal muscle cells associated with autolysis
4) Confidence 0.50 Published 2007 Journal Biotechnology Journal Section Body Doc Link PMC2978325 Disease Relevance 0.25 Pain Relevance 0.15
Another proteomic study using 2-DE and transgenic mice overexpressing p94 identified other glycolytic enzymes as p94 substrates in skeletal muscle [41], suggesting a role for p94 in the glycolytic cycle [42].
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of p94 in skeletal muscle associated with targeted disruption
5) Confidence 0.46 Published 2007 Journal Biotechnology Journal Section Body Doc Link PMC2978325 Disease Relevance 0.10 Pain Relevance 0

General Comments

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