INT342961

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Context Info
Confidence 0.43
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.10
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

intracellular (CAPN3) protein complex assembly (CAPN3) protein complex (CAPN3)
cytoplasm (CAPN3) signal transducer activity (CAPN3) cytosol (CAPN3)
CAPN3 (Homo sapiens)
Pain Link Frequency Relevance Heat
ischemia 6 5.00 Very Low Very Low Very Low
Pain 6 5.00 Very Low Very Low Very Low
addiction 3 5.00 Very Low Very Low Very Low
tolerance 3 5.00 Very Low Very Low Very Low
imagery 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Autolysis 15 99.20 Very High Very High Very High
Targeted Disruption 3 42.80 Quite Low
Pain 6 5.00 Very Low Very Low Very Low
Muscular Dystrophy 6 5.00 Very Low Very Low Very Low
Disease 6 5.00 Very Low Very Low Very Low
Brain Hemorrhage 3 5.00 Very Low Very Low Very Low
Embryonic Lethality 3 5.00 Very Low Very Low Very Low
Apoptosis 3 5.00 Very Low Very Low Very Low
Death 3 5.00 Very Low Very Low Very Low
Cv Unclassified Under Development 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, the observed local maximum with subsequent decay indicates that synthesis of p94 protein gradually decreased, which was probably due to proteolysis of the translation machinery by p94 as shown in iTRAQT™ experiments.
Negative_regulation (decreased) of Gene_expression (synthesis) of p94
1) Confidence 0.43 Published 2007 Journal Biotechnology Journal Section Body Doc Link PMC2978325 Disease Relevance 0 Pain Relevance 0
Similar decreases of all five peptides detected for WT p94 indicate that upon autolysis, different autolyzed fragments of WT p94 concurrently become more susceptible to subsequent degradation than unau-tolyzed p94 protein.
Negative_regulation (decreases) of Gene_expression (detected) of p94 associated with autolysis
2) Confidence 0.37 Published 2007 Journal Biotechnology Journal Section Body Doc Link PMC2978325 Disease Relevance 0.10 Pain Relevance 0
Proteins represented by peptides with reliable MS/MS spectra and whose signal ratios were decreased by WT p94 expression are listed in Table 2.
Negative_regulation (decreased) of Gene_expression (expression) of p94
3) Confidence 0.37 Published 2007 Journal Biotechnology Journal Section Body Doc Link PMC2978325 Disease Relevance 0 Pain Relevance 0

General Comments

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