INT342978

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Context Info
Confidence 0.25
First Reported 2010
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 2.05
Pain Relevance 1.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (Cd86)
Anatomy Link Frequency
B cell 4
lymph nodes 2
Cd86 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
spastic colon 279 99.36 Very High Very High Very High
Inflammation 90 90.04 High High
cytokine 54 68.40 Quite High
abdominal pain 6 16.76 Low Low
chemokine 18 5.00 Very Low Very Low Very Low
nud 9 5.00 Very Low Very Low Very Low
Pain 6 5.00 Very Low Very Low Very Low
Inflammatory response 6 5.00 Very Low Very Low Very Low
Lasting pain 3 5.00 Very Low Very Low Very Low
Visceral pain 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

276 99.36 Very High Very High Very High
INFLAMMATION 93 90.04 High High
Microscopic Colitis 21 50.24 Quite High
Syndrome 6 31.92 Quite Low
Diarrhoea 9 29.76 Quite Low
Congenital Anomalies 24 18.48 Low Low
Abdominal Pain 6 16.76 Low Low
Stress 33 5.00 Very Low Very Low Very Low
Inflammatory Bowel Disease 27 5.00 Very Low Very Low Very Low
Infection 15 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, the slight but significant difference in the over expression of IgG and alpha4beta7, together with the increased expression of CD80 and CD86, suggests that IBS patients also have increased B cell activation in the extra-intestinal lymph nodes.52 In order to explain this cellular infiltrate, Ohman and Simrén47 suggested 2 possible explanations: (1) It could be due to an unregulated mild inflammation or (2) It can reflect a potent inflammatory suppressive process led by activated T lymphocytes.
Positive_regulation (increased) of Gene_expression (expression) of CD86 in lymph nodes associated with inflammation and spastic colon
1) Confidence 0.25 Published 2010 Journal Journal of Neurogastroenterology and Motility Section Body Doc Link PMC2978389 Disease Relevance 0.36 Pain Relevance 0.64
The same group52 also described a state of B cell activation, finding increased CD80 and CD86 expression, at least in a subpopulation of IBS patients.
Spec (finding) Positive_regulation (finding) of Gene_expression (expression) of CD86 in B cell associated with spastic colon
2) Confidence 0.25 Published 2010 Journal Journal of Neurogastroenterology and Motility Section Body Doc Link PMC2978389 Disease Relevance 0.28 Pain Relevance 0.51
The same group52 also described a state of B cell activation, finding increased CD80 and CD86 expression, at least in a subpopulation of IBS patients.
Positive_regulation (increased) of Gene_expression (expression) of CD86 in B cell associated with spastic colon
3) Confidence 0.25 Published 2010 Journal Journal of Neurogastroenterology and Motility Section Body Doc Link PMC2978389 Disease Relevance 0.28 Pain Relevance 0.50

General Comments

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