INT342980

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Context Info
Confidence 0.03
First Reported 2010
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.07
Pain Relevance 0.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (TRPV1, PTAFR) cytosol (TRPV1) transport (TRPV1)
nucleolus (PTAFR) nucleus (PTAFR) signal transducer activity (PTAFR)
Anatomy Link Frequency
esophageal epithelium 2
TRPV1 (Homo sapiens)
HCL1 (Homo sapiens)
PTAFR (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 18 99.96 Very High Very High Very High
tetrodotoxin 3 98.16 Very High Very High Very High
substance P 27 75.20 Quite High
calcitonin gene related peptide 16 64.96 Quite High
Neurotransmitter 1 57.84 Quite High
Inflammation 37 50.00 Quite Low
Inflammatory mediators 14 41.68 Quite Low
cytokine 9 5.00 Very Low Very Low Very Low
chemokine 9 5.00 Very Low Very Low Very Low
qutenza 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Ganglion Cysts 1 66.56 Quite High
INFLAMMATION 48 50.00 Quite Low
Clostridium Difficile Infection 1 16.00 Low Low
Ileitis 1 14.68 Low Low
Colitis 1 12.48 Low Low
Esophageal Disease 22 5.00 Very Low Very Low Very Low
Gastroesophageal Reflux Disease 12 5.00 Very Low Very Low Very Low
Injury 5 5.00 Very Low Very Low Very Low
Acid Reflux 3 5.00 Very Low Very Low Very Low
Neurogenic Inflammation 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The HCl-induced increase in PAF was abolished by the TRPV1 receptor antagonist IRTX but not by neural block with tetrodotoxin, indicating that production of PAF may arise from non-neural pathways, and most likely from the esophageal epithelium.
TRPV1 receptor Neg (not) Negative_regulation (abolished) of HCl Positive_regulation (increase) of PAF in esophageal epithelium associated with tetrodotoxin and antagonist
1) Confidence 0.03 Published 2010 Journal Journal of Neurogastroenterology and Motility Section Body Doc Link PMC2978390 Disease Relevance 0.07 Pain Relevance 0.48

General Comments

This test has worked.

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