INT342985

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Context Info
Confidence 0.02
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.66
Pain Relevance 0.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL8, PPBP) extracellular region (IL8, PPBP) signal transduction (IL8)
intracellular (IL8)
Anatomy Link Frequency
neutrophils 1
IL8 (Homo sapiens)
PPBP (Homo sapiens)
Pain Link Frequency Relevance Heat
chemokine 9 100.00 Very High Very High Very High
substance P 27 87.36 High High
cytokine 9 84.76 Quite High
Inflammation 37 84.40 Quite High
calcitonin gene related peptide 16 66.40 Quite High
Inflammatory mediators 14 19.44 Low Low
antagonist 18 5.00 Very Low Very Low Very Low
qutenza 6 5.00 Very Low Very Low Very Low
tetrodotoxin 3 5.00 Very Low Very Low Very Low
TRP channel 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Esophageal Disease 22 98.84 Very High Very High Very High
Acid Reflux 3 94.20 High High
INFLAMMATION 48 84.40 Quite High
Injury 5 59.12 Quite High
Adhesions 1 49.92 Quite Low
Gastroesophageal Reflux Disease 12 37.64 Quite Low
Congenital Anomalies 1 15.00 Low Low
Neurogenic Inflammation 2 5.00 Very Low Very Low Very Low
Disease 2 5.00 Very Low Very Low Very Low
Ileitis 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
IL-8, a CXC chemokine with potent chemotactic activity for neutrophils, is elevated in the esophageal mucosa of esophagitis patients,11,65 suggesting a possible role of IL-8 in the pathogenesis of erosive esophagitis induced by acid reflux.
IL-8 Positive_regulation (elevated) of CXC chemokine in neutrophils associated with chemokine, esophageal disease and acid reflux
1) Confidence 0.02 Published 2010 Journal Journal of Neurogastroenterology and Motility Section Body Doc Link PMC2978390 Disease Relevance 0.66 Pain Relevance 0.30

General Comments

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