INT342988

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Context Info
Confidence 0.04
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 1.15
Pain Relevance 1.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (TRPV1) transport (TRPV1) plasma membrane (TRPV1)
lipid metabolic process (TRPV1)
Anatomy Link Frequency
Epithelial cells 2
muscle 1
HCL1 (Homo sapiens)
TRPV1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 111 99.60 Very High Very High Very High
cytokine 27 99.44 Very High Very High Very High
Inflammatory mediators 42 98.88 Very High Very High Very High
substance P 81 96.72 Very High Very High Very High
calcitonin gene related peptide 48 96.44 Very High Very High Very High
qutenza 18 95.48 Very High Very High Very High
antagonist 54 90.52 High High
agonist 6 81.12 Quite High
tetrodotoxin 9 47.92 Quite Low
chemokine 27 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 144 99.60 Very High Very High Very High
Esophageal Disease 66 85.32 High High
Muscle Hypertonia 3 44.52 Quite Low
Ganglion Cysts 3 9.64 Low Low
Gastroesophageal Reflux Disease 36 5.00 Very Low Very Low Very Low
Injury 15 5.00 Very Low Very Low Very Low
Acid Reflux 9 5.00 Very Low Very Low Very Low
Neurogenic Inflammation 6 5.00 Very Low Very Low Very Low
Disease 6 5.00 Very Low Very Low Very Low
Ileitis 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We conclude that HCl-induced activation of TRPV1 receptors in esophageal epithelial cells results in neurally mediated release of SP and CGRP, and non-neurally mediated release of PAF from the epithelium (Fig. 9).

7.

HCl Positive_regulation (activation) of TRPV1 in epithelial cells associated with calcitonin gene related peptide and substance p
1) Confidence 0.04 Published 2010 Journal Journal of Neurogastroenterology and Motility Section Body Doc Link PMC2978390 Disease Relevance 0.26 Pain Relevance 0.64
Epithelial cells, not only constitute the first barrier to diffusion of refluxate, but are important participants in inflammation as they respond to HCl-mediated activation of TRPV1 by releasing cytokines and inflammatory mediators.
HCl Positive_regulation (activation) of TRPV1 in Epithelial cells associated with inflammatory mediators, inflammation and cytokine
2) Confidence 0.04 Published 2010 Journal Journal of Neurogastroenterology and Motility Section Body Doc Link PMC2978390 Disease Relevance 0.89 Pain Relevance 0.37
HCl-induced activation of TRPV1 receptors, affects contraction of esophageal circular muscle as electric field stimulation (EFS)-induced contraction of esophageal circular strips was almost abolished by incubation in the supernatant of the HCl-filled mucosal sac (Fig. 7).
HCl Positive_regulation (activation) of TRPV1 in muscle
3) Confidence 0.04 Published 2010 Journal Journal of Neurogastroenterology and Motility Section Body Doc Link PMC2978390 Disease Relevance 0 Pain Relevance 0.19

General Comments

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