INT342990

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Context Info
Confidence 0.06
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.44
Pain Relevance 1.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (TRPV1) extracellular space (SFTPA1) transport (TRPV1)
extracellular region (SFTPA1) plasma membrane (TRPV1) lipid metabolic process (TRPV1)
Anatomy Link Frequency
immune cells 2
neural 2
TRPV1 (Homo sapiens)
SFTPA1 (Homo sapiens)
Pain Link Frequency Relevance Heat
substance P 54 100.00 Very High Very High Very High
calcitonin gene related peptide 32 99.80 Very High Very High Very High
tetrodotoxin 6 99.64 Very High Very High Very High
antagonist 36 98.30 Very High Very High Very High
Inflammation 74 96.84 Very High Very High Very High
Neurotransmitter 2 95.76 Very High Very High Very High
Inflammatory mediators 28 87.84 High High
chemokine 18 83.36 Quite High
cytokine 18 67.28 Quite High
burning pain 2 31.72 Quite Low
Disease Link Frequency Relevance Heat
INFLAMMATION 96 96.84 Very High Very High Very High
Injury 10 96.16 Very High Very High Very High
Acid Reflux 6 92.08 High High
Esophageal Disease 44 91.16 High High
Ganglion Cysts 2 77.60 Quite High
Gastroesophageal Reflux Disease 24 64.96 Quite High
Clostridium Difficile Infection 2 62.16 Quite High
Ileitis 2 60.84 Quite High
Colitis 2 58.64 Quite High
Neurogenic Inflammation 4 39.16 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
SP and CGRP levels increased in mucosal tissue and in supernatant in response to HCl (Fig. 2 and 3) and the increases were abolished by the TRPV1 receptor antagonist 5'-iodoresinferratoxin (IRTX) or by neural block with tetrodotoxin, suggesting that TRPV1-induced production of SP and CGRP was neurally mediated.
TRPV1 Positive_regulation (induced) of Gene_expression (production) of SP in neural associated with tetrodotoxin, calcitonin gene related peptide, antagonist and substance p
1) Confidence 0.06 Published 2010 Journal Journal of Neurogastroenterology and Motility Section Body Doc Link PMC2978390 Disease Relevance 0.59 Pain Relevance 0.82
We propose that acid in the lumen of the esophagus activates TRPV1 receptors causing the production and release of PAF, SP and CGRP that, in turn, may attract and activate immune cells contributing to inflammation and injury of the esophageal mucosa.
TRPV1 Positive_regulation (causing) of Gene_expression (production) of SP in immune cells associated with calcitonin gene related peptide, inflammation, injury and substance p
2) Confidence 0.05 Published 2010 Journal Journal of Neurogastroenterology and Motility Section Body Doc Link PMC2978390 Disease Relevance 0.84 Pain Relevance 0.43

General Comments

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