INT342991

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Context Info
Confidence 0.03
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.71
Pain Relevance 0.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (CALCA) aging (CALCA) extracellular region (CALCA)
nucleus (CALCA) intracellular (CALCA) cell-cell signaling (CALCA)
Anatomy Link Frequency
neural 1
HCL1 (Homo sapiens)
CALCA (Homo sapiens)
Pain Link Frequency Relevance Heat
calcitonin gene related peptide 16 100.00 Very High Very High Very High
substance P 27 99.90 Very High Very High Very High
Inflammatory mediators 14 97.56 Very High Very High Very High
antagonist 18 97.16 Very High Very High Very High
tetrodotoxin 3 94.56 High High
Inflammation 37 81.36 Quite High
Neurotransmitter 1 80.08 Quite High
burning pain 1 41.44 Quite Low
qutenza 6 17.92 Low Low
cytokine 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 48 97.16 Very High Very High Very High
Clostridium Difficile Infection 1 71.88 Quite High
Ileitis 1 70.56 Quite High
Colitis 1 68.36 Quite High
Ganglion Cysts 1 61.92 Quite High
Neurogenic Inflammation 2 48.88 Quite Low
Pain 1 41.44 Quite Low
Esophageal Disease 22 37.92 Quite Low
Inflammatory Bowel Disease 1 35.44 Quite Low
Disease 2 32.56 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
SP and CGRP levels increased in mucosal tissue and in supernatant in response to HCl (Fig. 2 and 3) and the increases were abolished by the TRPV1 receptor antagonist 5'-iodoresinferratoxin (IRTX) or by neural block with tetrodotoxin, suggesting that TRPV1-induced production of SP and CGRP was neurally mediated.
HCl Positive_regulation (increased) of CGRP in neural associated with tetrodotoxin, calcitonin gene related peptide, antagonist and substance p
1) Confidence 0.03 Published 2010 Journal Journal of Neurogastroenterology and Motility Section Body Doc Link PMC2978390 Disease Relevance 0.71 Pain Relevance 0.84

General Comments

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