INT342994

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Context Info
Confidence 0.09
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.39
Pain Relevance 0.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (IL1B) signal transducer activity (PTAFR) cell-cell signaling (IL1B)
cytosol (IL1B) extracellular space (IL1B) signal transduction (IL1B)
Anatomy Link Frequency
muscle 2
IL1B (Homo sapiens)
PTAFR (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 37 94.16 High High
antagonist 18 83.68 Quite High
Inflammatory mediators 14 37.72 Quite Low
calcitonin gene related peptide 16 27.36 Quite Low
substance P 27 27.00 Quite Low
qutenza 6 17.88 Low Low
cytokine 9 16.64 Low Low
chemokine 9 5.00 Very Low Very Low Very Low
tetrodotoxin 3 5.00 Very Low Very Low Very Low
TRP channel 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 48 94.16 High High
Congenital Anomalies 1 92.08 High High
Gastroesophageal Reflux Disease 12 46.08 Quite Low
Adhesions 1 21.84 Low Low
Esophageal Disease 22 5.00 Very Low Very Low Very Low
Injury 5 5.00 Very Low Very Low Very Low
Acid Reflux 3 5.00 Very Low Very Low Very Low
Neurogenic Inflammation 2 5.00 Very Low Very Low Very Low
Disease 2 5.00 Very Low Very Low Very Low
Ileitis 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This indicates that PAF is a major mucosa-derived mediator depressing muscle contraction.41 PAF can also activate the esophageal circular muscle to secrete IL-6.41 The muscle-derived IL-6 then leads to enhanced production of H2O2, which in turn induces the secretion of IL-1.41,42 H2O2 and IL-1 can themselves induce PAF production (Fig. 13).
IL-1 Positive_regulation (induce) of Gene_expression (production) of PAF in muscle
1) Confidence 0.09 Published 2010 Journal Journal of Neurogastroenterology and Motility Section Body Doc Link PMC2978390 Disease Relevance 0.39 Pain Relevance 0.22

General Comments

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