INT342998

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Context Info
Confidence 0.23
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.25
Pain Relevance 0.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (DUOX1, ROS1) cell differentiation (ROS1) cell proliferation (ROS1)
oxidoreductase activity (DUOX1)
DUOX1 (Homo sapiens)
ROS1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 9 95.92 Very High Very High Very High
Inflammation 37 86.96 High High
chemokine 9 74.16 Quite High
substance P 27 73.24 Quite High
antagonist 18 70.20 Quite High
calcitonin gene related peptide 16 63.52 Quite High
Inflammatory mediators 14 60.84 Quite High
qutenza 6 5.00 Very Low Very Low Very Low
tetrodotoxin 3 5.00 Very Low Very Low Very Low
TRP channel 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hyperplasia 1 98.44 Very High Very High Very High
INFLAMMATION 48 86.96 High High
Gastroesophageal Reflux Disease 12 24.72 Low Low
Injury 5 11.12 Low Low
Esophageal Disease 22 5.00 Very Low Very Low Very Low
Acid Reflux 3 5.00 Very Low Very Low Very Low
Neurogenic Inflammation 2 5.00 Very Low Very Low Very Low
Disease 2 5.00 Very Low Very Low Very Low
Ileitis 1 5.00 Very Low Very Low Very Low
Death 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
ROS comprise species such as superoxide, H2O2, nitric oxide and hydroxyl radicals.79 These highly reactive molecules are known to regulate many important cellular events, including gene expression,80 transcription factor activation,81 DNA synthesis82 and cellular proliferation.83 The enzymes nicotinamide adenine dinucleotide phosphate oxidase (NOX) and dual oxidase generate ROS in a regulated manner, producing reactive oxygen in cells and tissues in response to growth factors, cytokines and calcium signals.84
dual oxidase Positive_regulation (generate) of ROS associated with hyperplasia and cytokine
1) Confidence 0.23 Published 2010 Journal Journal of Neurogastroenterology and Motility Section Body Doc Link PMC2978390 Disease Relevance 0.25 Pain Relevance 0.43

General Comments

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