INT343009

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Context Info
Confidence 0.05
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.42
Pain Relevance 0.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (SFTPA1) extracellular region (SFTPA1)
Anatomy Link Frequency
digestive tract 2
SFTPA1 (Homo sapiens)
Pain Link Frequency Relevance Heat
substance P 27 100.00 Very High Very High Very High
Inflammation 37 99.84 Very High Very High Very High
calcitonin gene related peptide 16 84.92 Quite High
burning pain 1 80.40 Quite High
qutenza 6 56.88 Quite High
TRP channel 2 42.48 Quite Low
Inflammatory mediators 14 32.24 Quite Low
Bile 1 27.00 Quite Low
antagonist 18 13.76 Low Low
cytokine 9 13.16 Low Low
Disease Link Frequency Relevance Heat
INFLAMMATION 48 99.84 Very High Very High Very High
Colitis 1 94.72 High High
Ileitis 1 92.52 High High
Clostridium Difficile Infection 1 91.76 High High
Neurogenic Inflammation 2 87.84 High High
Pain 1 80.40 Quite High
Esophageal Disease 22 76.88 Quite High
Inflammatory Bowel Disease 1 74.40 Quite High
Disease 2 71.52 Quite High
Gastroesophageal Reflux Disease 12 61.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the digestive tract most publications have focused on the role of vanilloid receptor in inflammation, with emphasis on stimulation of SP release,22-31 or on a role of endopeptidases in degradation of SP, with a resulting decrease in inflammation.32-34 In the ileum and colon, TRPV1 is thought to be a mediator of inflammation because, in experimental models of colitis induced by dextran sulphate sodium,35,36 or of ileitis induced by Clostridium difficile toxin A28 or anandamide,27 inflammation is attenuated in response to TRPV1 channel blockers35,36 or after genetic deletion of TRPV1.37
Negative_regulation (decrease) of Protein_catabolism (degradation) of SP in digestive tract associated with colitis, clostridium difficile infection, inflammation, ileitis and substance p
1) Confidence 0.05 Published 2010 Journal Journal of Neurogastroenterology and Motility Section Body Doc Link PMC2978390 Disease Relevance 1.42 Pain Relevance 0.79

General Comments

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