INT343012

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Context Info
Confidence 0.04
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.33
Pain Relevance 1.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
epithelial cells 1
HCL1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 74 97.36 Very High Very High Very High
substance P 54 96.36 Very High Very High Very High
calcitonin gene related peptide 32 96.08 Very High Very High Very High
qutenza 12 95.48 Very High Very High Very High
antagonist 36 90.52 High High
Inflammatory mediators 28 83.68 Quite High
tetrodotoxin 6 81.68 Quite High
agonist 4 81.12 Quite High
Neurotransmitter 2 63.44 Quite High
cytokine 18 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 96 97.36 Very High Very High Very High
Ganglion Cysts 2 72.16 Quite High
Clostridium Difficile Infection 2 21.60 Low Low
Ileitis 2 20.28 Low Low
Colitis 2 18.08 Low Low
Esophageal Disease 44 5.00 Very Low Very Low Very Low
Gastroesophageal Reflux Disease 24 5.00 Very Low Very Low Very Low
Injury 10 5.00 Very Low Very Low Very Low
Acid Reflux 6 5.00 Very Low Very Low Very Low
Neurogenic Inflammation 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
PAF levels increased in the HCl-filled mucosal sac and in its supernatant when compared to controls (Krebs filled mucosal sac at pH 7.4) (Fig. 5).
Positive_regulation (increased) of HCl
1) Confidence 0.04 Published 2010 Journal Journal of Neurogastroenterology and Motility Section Body Doc Link PMC2978390 Disease Relevance 0.07 Pain Relevance 0.48
We conclude that HCl-induced activation of TRPV1 receptors in esophageal epithelial cells results in neurally mediated release of SP and CGRP, and non-neurally mediated release of PAF from the epithelium (Fig. 9).

7.

Positive_regulation (activation) of HCl in epithelial cells associated with calcitonin gene related peptide and substance p
2) Confidence 0.04 Published 2010 Journal Journal of Neurogastroenterology and Motility Section Body Doc Link PMC2978390 Disease Relevance 0.25 Pain Relevance 0.64

General Comments

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