INT343014

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Context Info
Confidence 0.01
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.37
Pain Relevance 0.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
muscle 1
HIST2H2AA3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 37 90.48 High High
antagonist 18 85.00 Quite High
Inflammatory mediators 14 39.04 Quite Low
calcitonin gene related peptide 16 28.68 Quite Low
substance P 27 28.32 Quite Low
qutenza 6 19.20 Low Low
cytokine 9 12.96 Low Low
chemokine 9 5.00 Very Low Very Low Very Low
tetrodotoxin 3 5.00 Very Low Very Low Very Low
TRP channel 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 48 90.48 High High
Congenital Anomalies 1 88.40 High High
Gastroesophageal Reflux Disease 12 42.40 Quite Low
Adhesions 1 18.16 Low Low
Esophageal Disease 22 5.00 Very Low Very Low Very Low
Injury 5 5.00 Very Low Very Low Very Low
Acid Reflux 3 5.00 Very Low Very Low Very Low
Neurogenic Inflammation 2 5.00 Very Low Very Low Very Low
Disease 2 5.00 Very Low Very Low Very Low
Ileitis 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This indicates that PAF is a major mucosa-derived mediator depressing muscle contraction.41 PAF can also activate the esophageal circular muscle to secrete IL-6.41 The muscle-derived IL-6 then leads to enhanced production of H2O2, which in turn induces the secretion of IL-1.41,42 H2O2 and IL-1 can themselves induce PAF production (Fig. 13).
Localization (secretion) of H2O2 in muscle
1) Confidence 0.01 Published 2010 Journal Journal of Neurogastroenterology and Motility Section Body Doc Link PMC2978390 Disease Relevance 0.37 Pain Relevance 0.21

General Comments

This test has worked.

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