INT343178

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Context Info
Confidence 0.41
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.92
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (ACSL4) small molecule metabolic process (ACSL4) endoplasmic reticulum (ACSL4)
peroxisome (ACSL4) ligase activity (ACSL4)
ACSL4 (Homo sapiens)
Pain Link Frequency Relevance Heat
COX-2 inhibitor 1 76.48 Quite High
COX2 1 5.00 Very Low Very Low Very Low
cINOD 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 12 97.12 Very High Very High Very High
Bladder Cancer 1 95.56 Very High Very High Very High
Cancer 14 89.48 High High
Colon Cancer 9 87.84 High High
Breast Cancer 37 76.12 Quite High
Injury 21 5.00 Very Low Very Low Very Low
Aggression 6 5.00 Very Low Very Low Very Low
Hepatocellular Cancer 5 5.00 Very Low Very Low Very Low
Targeted Disruption 4 5.00 Very Low Very Low Very Low
Wound Healing 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is therefore unlikely that the inhibition of ACSL4-stimulated COX-2 expression by AA861 reported here may be due to an activation of apoptosis or inhibition of cell growth or survival since the inhibition of COX-2 expression is evident at least 48 h earlier than the inhibition in cell proliferation described for different cancer cell lines.
Negative_regulation (inhibition) of Positive_regulation (stimulated) of ACSL4 associated with cancer and apoptosis
1) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2978721 Disease Relevance 0.92 Pain Relevance 0.04

General Comments

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