INT343181

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Context Info
Confidence 0.59
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 1.26
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (ACSL4) small molecule metabolic process (ACSL4) endoplasmic reticulum (ACSL4)
peroxisome (ACSL4) ligase activity (ACSL4)
ACSL4 (Homo sapiens)
Pain Link Frequency Relevance Heat
COX2 3 5.00 Very Low Very Low Very Low
COX-2 inhibitor 3 5.00 Very Low Very Low Very Low
cINOD 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Breast Cancer 111 99.16 Very High Very High Very High
Repression 3 90.48 High High
Cancer 42 79.28 Quite High
Advanced Or Metastatic Breast Cancer 3 66.92 Quite High
Hepatocellular Cancer 15 59.84 Quite High
Colon Cancer 27 58.64 Quite High
Aggression 18 57.68 Quite High
Apoptosis 36 49.68 Quite Low
Liver Cancer 3 28.56 Quite Low
Injury 63 11.52 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
After several weeks, colonies in which the expressed ACSL4 was regulated by tetracycline (2 µg/ml) were selected, cultured and subjected to different functional assays.
Regulation (regulated) of ACSL4
1) Confidence 0.59 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2978721 Disease Relevance 0.09 Pain Relevance 0
The finding that tetracycline abolished the expression of COX-2 strongly indicates that COX-2 expression is under the control of ACSL4 levels.
Regulation (control) of ACSL4
2) Confidence 0.59 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2978721 Disease Relevance 0.12 Pain Relevance 0
Functionally, we found that ACSL4 is part of the mechanism responsible for the increase in breast cancer cell proliferation, invasion and migration.
Regulation (responsible) of ACSL4 associated with breast cancer
3) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2978721 Disease Relevance 1.05 Pain Relevance 0

General Comments

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